(Q40718061)

English

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

scientific article published on 15 July 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch (English)

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Peter Henry St George-Hyslop

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Peter St George-Hyslop

9

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author name string

Fusheng Chen

1

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

YongJun Gu

2

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Hiroshi Hasegawa

3

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Xueying Ruan

4

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Shigeki Arawaka

5

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Paul Fraser

6

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

David Westaway

7

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Howard Mount

8

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

language of work or name

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publication date

15 July 2002

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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23 September 2017

277

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Europe PubMed Central

PubMed publication ID

23 September 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

36521-36526

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased A beta42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M205093200

21 January 2018

Identifiers

10.1074/JBC.M205093200

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

23 September 2017

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