(Q24321405)

regulation of amyloid-beta formation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Ekaterina Rogaeva

Peter Henry St George-Hyslop

10

0 references

19

0 references

Gerold Schmitt-Ulms

3

0 references

David Westaway

18

0 references

Philippe Marambaud

16

0 references

Nobuo Sanjo

Nobuo Sanjo

8

0 references

Frédéric Checler

Frédéric Checler

15

0 references

Toshitaka Kawarai

4

Toshitaka Kawarai

0 references

Anurag Tandon

14

Anurag Tandon

0 references

Yosuke Wakutani

11

Yosuke Wakutani

0 references

Christopher Bohm

5

Christopher Bohm

0 references

Taiichi Katayama

6

Taiichi Katayama

0 references

author name string

Fusheng Chen

1

0 references

Hiroshi Hasegawa

2

0 references

Yongjun Gu

7

0 references

Michael Glista

9

0 references

Raphaëlle Pardossi-Piquard

12

0 references

Xueying Ruan

13

0 references

Kirk Hansen

17

0 references

Paul Fraser

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

20

0 references

language of work or name

English

0 references

publication date

27 April 2006

0 references

published in

Nature

0 references

volume

440

0 references

issue

7088

0 references

page(s)

1208-12

0 references

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

A system for enhancing genome-wide coexpression dynamics study.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

p24 proteins and quality control of LIN-12 and GLP-1 trafficking in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Gamma-secretase: proteasome of the membrane?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04667

7 January 2021