(Q30811532)

26 June 2017

title

Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides (English)

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26 June 2017

main subject

transmembrane protein

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6

Dennis J Selkoe

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26 June 2017

Jimin Zhang

1

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26 June 2017

Wenjuan Ye

2

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26 June 2017

Rong Wang

3

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26 June 2017

Michael S Wolfe

4

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26 June 2017

Barry D Greenberg

5

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26 June 2017

language of work or name

English

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publication date

11 February 2002

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Journal of Biological Chemistry

26 June 2017

published in

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26 June 2017

volume

277

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26 June 2017

issue

17

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26 June 2017

page(s)

15069-15075

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

26 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

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Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

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Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling

21 January 2018

1 reference

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Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

21 January 2018

1 reference

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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

21 January 2018

1 reference

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Evidence for a physical interaction between presenilin and Notch

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

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Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

21 January 2018

1 reference

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Generation of amyloid beta protein from its precursor is sequence specific

21 January 2018

1 reference

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

1 reference

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

21 January 2018

1 reference

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

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Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

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Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

21 January 2018

1 reference

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gamma-secretase cleavage is distinct from endoplasmic reticulum degradation of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

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Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

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Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation

21 January 2018

1 reference

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Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

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The Alzheimer family of diseases: many etiologies, one pathogenesis?

21 January 2018

1 reference

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Amyloid precursor protein processing in sterol regulatory element-binding protein site 2 protease-deficient Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M105375200

21 January 2018

Identifiers

DOI

10.1074/JBC.M105375200

1 reference

26 June 2017

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