(Q39972714)

English

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

transmembrane protein

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3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

author name string

Chihiro Sato

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Shizuka Takagi

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Takeshi Iwatsubo

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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publication date

1 June 2008

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

28

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

24

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

6264-6271

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How proteins adapt to a membrane-water interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein mobility and GABA-induced conformational changes in GABA(A) receptor pore-lining M2 segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid distributions in integral membrane protein structures

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kamikaze approach to membrane transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Designed Helical Peptides Inhibit an Intramembrane Protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intramembrane proteolysis: theme and variations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of a structural model of the ATP-binding site of the KATP channel Kir6.2 subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that the COOH terminus of human presenilin 1 is located in extracytoplasmic space

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel transmembrane topology of presenilin based on reconciling experimental and computational evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A nine-transmembrane domain topology for presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-secretase as a therapeutic target for treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional structure of the γ-secretase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structure of a rhomboid family intramembrane protease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of inward rectifier K channel activity by lipid tethering of cytoplasmic domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin: running with scissors in the membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of a site-2 protease family intramembrane metalloprotease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting proteins within lipid bilayers: rhomboid structure and mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proline kinks in transmembrane alpha-helices

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A measure of helical propensity for amino acids in membrane environments

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substituted-cysteine accessibility method

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual roles of proteasome in the metabolism of presenilin 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18550769

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1163-08.2008

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

release_ym6kefyxqvddvfzkl4k7s2uvl4

1 reference

https://api.fatcat.wiki/v0/release/ym6kefyxqvddvfzkl4k7s2uvl4

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18550769%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

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