(Q35757335)

10 August 2017

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title

On the mechanism of SPP-catalysed intramembrane proteolysis; conformational control of peptide bond hydrolysis in the plane of the membrane (English)

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10 August 2017

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Marius K Lemberg

1

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10 August 2017

Bruno Martoglio

series ordinal

2

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10 August 2017

language of work or name

English

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publication date

1 April 2004

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10 August 2017

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10 August 2017

volume

564

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10 August 2017

issue

3

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10 August 2017

page(s)

213-218

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Protease degradomics: a new challenge for proteomics

10 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila

7 January 2021

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

7 January 2021

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

7 January 2021

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

7 January 2021

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

7 January 2021

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Identification of signal peptide peptidase, a presenilin-type aspartic protease

7 January 2021

1 reference

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HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C

7 January 2021

1 reference

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Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

7 January 2021

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Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

7 January 2021

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Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

7 January 2021

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

7 January 2021

1 reference

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Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

7 January 2021

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Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

7 January 2021

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Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

7 January 2021

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

7 January 2021

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Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

7 January 2021

1 reference

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Crystal structure of rhodopsin: implications for vision and beyond

7 January 2021

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

7 January 2021

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Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

7 January 2021

1 reference

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Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

7 January 2021

1 reference

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Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

7 January 2021

1 reference

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PhoE signal peptide inserts into micelles as a dynamic helix-break-helix structure, which is modulated by the environment. A two-dimensional 1H NMR study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Helical membrane protein folding, stability, and evolution

7 January 2021

1 reference

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The structural aspects of limited proteolysis of native proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Protein–lipid interactions studied with designed transmembrane peptides: role of hydrophobic matching and interfacial anchoring (Review)

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

A measure of helical propensity for amino acids in membrane environments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Peptides in membranes: Helicity and hydrophobicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Free-energy determinants of alpha-helix insertion into lipid bilayers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Putting the beta-breaks on membrane protein misfolding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Membrane protein folding and stability: physical principles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

A transmembrane helix dimer: structure and implications

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Reexamination of induced fit as a determinant of substrate specificity in enzymatic reactions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

"Secretase," Alzheimer amyloid protein precursor secreting enzyme is not sequence-specific

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Mutational analysis of the membrane-proximal cleavage site of L-selectin: relaxed sequence specificity surrounding the cleavage site

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Role of the Juxtamembrane Domains of the Transforming Growth Factor-α Precursor and the β-Amyloid Precursor Protein in Regulated Ectodomain Shedding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2804%2900192-9

10.1016/S0014-5793(04)00192-9

7 January 2021

Identifiers

DOI

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10 August 2017

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