(Q44367163)

2 December 2017

title

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications (English)

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2 December 2017

Anna Y Kornilova

1

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2 December 2017

Chittaranjan Das

series ordinal

2

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2 December 2017

Michael S Wolfe

series ordinal

3

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2 December 2017

language of work or name

English

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publication date

18 March 2003

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Journal of Biological Chemistry

2 December 2017

published in

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2 December 2017

volume

278

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2 December 2017

issue

19

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2 December 2017

page(s)

16470-16473

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Secretase targets for Alzheimer's disease: identification and therapeutic potential

2 December 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.C300019200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Biochemistry. Intramembrane proteases--mixing oil and water

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

The Role of presenilins in gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Identification of a novel family of presenilin homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

A portrait of Alzheimer secretases--new features and familiar faces

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300019200

21 January 2018

Identifiers

DOI

10.1074/JBC.C300019200

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2 December 2017

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