(Q40447332)

20 September 2017

title

Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. (English)

1 reference

Peter Henry St George-Hyslop

20 September 2017

author

object named as

Peter St George-Hyslop

15

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Bart De Strooper

9

object named as

Bart De Strooper

1 reference

20 September 2017

Yoshifumi Nakaya

1

1 reference

20 September 2017

Takuya Yamane

2

1 reference

20 September 2017

Hirohisa Shiraishi

3

1 reference

20 September 2017

Hua-Qin Wang

4

1 reference

20 September 2017

Etsuro Matsubara

5

1 reference

20 September 2017

Toru Sato

6

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20 September 2017

Georgia Dolios

7

1 reference

20 September 2017

Rong Wang

8

1 reference

20 September 2017

Mikio Shoji

10

1 reference

20 September 2017

Hiroto Komano

11

1 reference

20 September 2017

Katsuhiko Yanagisawa

12

1 reference

20 September 2017

Yasuo Ihara

13

1 reference

20 September 2017

Paul Fraser

14

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20 September 2017

Masaki Nishimura

16

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20 September 2017

language of work or name

English

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publication date

10 March 2005

1 reference

Journal of Biological Chemistry

20 September 2017

published in

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20 September 2017

volume

280

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20 September 2017

issue

19

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20 September 2017

page(s)

19070-19077

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Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

20 September 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

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The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

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Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

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Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding

21 January 2018

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21 January 2018

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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A new functional screening system for identification of regulators for the generation of amyloid beta-protein

21 January 2018

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Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

21 January 2018

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21 January 2018

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

21 January 2018

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Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

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Biochemical characterization of the gamma-secretase activity that produces beta-amyloid peptides

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

21 January 2018

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Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

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Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase

21 January 2018

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Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis

21 January 2018

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Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

21 January 2018

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21 January 2018

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Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

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21 January 2018

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

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21 January 2018

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21 January 2018

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M501130200

1 reference

20 September 2017

1 reference