(Q30876784)

English

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".

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Europe PubMed Central

PubMed publication ID

27 June 2017

Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase". (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Alzheimer's disease

1 reference

based on heuristic

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author name string

Takeshi Ikeuchi

1

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Georgia Dolios

2

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Seong-Hun Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Rong Wang

4

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Sangram S Sisodia

5

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

language of work or name

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publication date

19 December 2002

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

27 June 2017

278

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Europe PubMed Central

PubMed publication ID

27 June 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

7010-7018

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Biochemistry. Intramembrane proteases--mixing oil and water

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

High-efficiency transformation of mammalian cells by plasmid DNA

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilins are not required for A beta 42 production in the early secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M209252200

21 January 2018

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10.1074/JBC.M209252200

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

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