(Q48529619)

12 February 2018

title

Presenilins are not required for A beta 42 production in the early secretory pathway. (English)

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12 February 2018

author name string

Christina A Wilson

1

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12 February 2018

Robert W Doms

2

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12 February 2018

Hui Zheng

3

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12 February 2018

Virginia M-Y Lee

4

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12 February 2018

language of work or name

English

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publication date

1 September 2002

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12 February 2018

published in

Nature Neuroscience

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12 February 2018

volume

5

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12 February 2018

issue

9

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12 February 2018

page(s)

849-855

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12 February 2018

https://scigraph.springernature.com/pub.10.1038/nn898

exact match

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cites work

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Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

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7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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7 January 2021

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

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7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

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7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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7 January 2021

Generation of amyloid beta protein from its precursor is sequence specific

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7 January 2021

Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum

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7 January 2021

Pre- and post-Golgi vacuoles operate in the transport of Semliki Forest virus membrane glycoproteins to the cell surface

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7 January 2021

Endogenous beta-amyloid production in presenilin-deficient embryonic mouse fibroblasts

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7 January 2021

The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

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7 January 2021

A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP

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7 January 2021

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

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7 January 2021

Cellular mechanisms of beta-amyloid production and secretion

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7 January 2021

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

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7 January 2021

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

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7 January 2021

Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage

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7 January 2021

Identification of a novel family of presenilin homologues

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7 January 2021

Identification of signal peptide peptidase, a presenilin-type aspartic protease

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7 January 2021

Intracellular APP processing and A beta production in Alzheimer disease

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7 January 2021

Intraneuronal Abeta42 accumulation in human brain.

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7 January 2021

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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7 January 2021

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

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7 January 2021

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

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7 January 2021

Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis

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7 January 2021

Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease

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7 January 2021

Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein

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7 January 2021

Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42.

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

1 reference

7 January 2021

Identifiers

DOI

10.1038/NN898

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12 February 2018

PubMed ID

12145638

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12 February 2018