(Q40942994)

25 September 2017

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase (English)

1 reference

25 September 2017

Durkin JT

1

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25 September 2017

Murthy S

2

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25 September 2017

Husten EJ

3

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25 September 2017

Trusko SP

4

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25 September 2017

Savage MJ

5

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25 September 2017

Rotella DP

6

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25 September 2017

Greenberg BD

7

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25 September 2017

Siman R

8

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25 September 2017

language of work or name

English

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publication date

1 July 1999

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Journal of Biological Chemistry

25 September 2017

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25 September 2017

274

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25 September 2017

29

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25 September 2017

20499-20504

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Therapeutic approaches related to amyloid-beta peptide and Alzheimer's disease

25 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Amyloid beta-protein and the genetics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Amyloid beta protein (Abeta) deposition in chromosome 14-linked Alzheimer's disease: predominance of Abeta42(43).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Evidence that A beta 42 is the real culprit in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Amyloid, the presenilins and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Strategies to alter the progression of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Specificity in the binding of inhibitors to the active site of human/primate aspartic proteinases: analysis of P2-P1-P1'-P2' variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Cathepsin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Inhibition of beta-amyloid formation identifies proteolytic precursors and subcellular site of catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Elevated Aβ levels in Alzheimer's disease brain are associated with selective accumulation of Aβ42 in parenchymal amyloid plaques and both Aβ40 and Aβ42 in cerebrovascular deposits

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Overexpression of a COOH-terminal fragment of β-amyloid precursor protein in HeLa cells results in accumulation in a pre-Golgi compartment and generation of an Aβ-like fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Polyclonals to beta-amyloid(1-42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

The carboxyl termini of beta-amyloid peptides 1-40 and 1-42 are generated by distinct gamma-secretase activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

Synthesis of a new cell penetrating calpain inhibitor (calpeptin)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20499

21 January 2018

Identifiers

DOI

10.1074/JBC.274.29.20499

1 reference

25 September 2017

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