(Q31100408)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity (English)

1 reference

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11 November 2019

1

1 reference

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11 November 2019

author name string

Jonathan D J Wrigley

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Andrew P Owens

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Mark S Shearman

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

language of work or name

English

0 references

publication date

1 August 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

Journal of Neurochemistry

11 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

volume

82

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

page(s)

563-575

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12153480%20AND%20SRC:MED&resulttype=core&format=json

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

11 November 2019

cites work

1 reference

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

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Generation of beta A4 from the amyloid protein precursor and fragments thereof

21 January 2018

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

21 January 2018

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Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum

21 January 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

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Intracellular production of beta A4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein

21 January 2018

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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The Alzheimer family of diseases: many etiologies, one pathogenesis?

21 January 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

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Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

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Modulation of amyloid precursor protein processing by compounds with various mechanisms of action: detection by liquid phase electrochemiluminescent system

21 January 2018

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

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A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

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The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain

21 January 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

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Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design

21 January 2018

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Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging

21 January 2018

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Alzheimer's amyloid precursor protein alpha-secretase is inhibited by hydroxamic acid-based zinc metalloprotease inhibitors: similarities to the angiotensin converting enzyme secretase

21 January 2018

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry

21 January 2018

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.

21 January 2018

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A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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Processing of tumour necrosis factor-α precursor by metalloproteinases

21 January 2018

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