(Q40795985)

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Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11429407%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11429407%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

transmembrane protein

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multiple drug resistance

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based on heuristic

inferred from title

1

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9 November 2019

author name string

Clarke DM

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9 November 2019

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27 June 2001

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9 November 2019

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6

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Journal of Biological Chemistry

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9 November 2019

276

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9 November 2019

31800-31805

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9 November 2019

34

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9 November 2019

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Multidrug resistance in oncology: diagnostic and therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

The minimum functional unit of human P-glycoprotein appears to be a monomer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

The catalytic cycle of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

A kinetic model for the action of a resistance efflux pump.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Identification of the cyclosporin-binding site in P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Diagnosis and reversal of multidrug resistance in paediatric cancers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Analysis of MDR1 P-glycoprotein conformational changes in permeabilized cells using differential immunoreactivity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

FRET analysis indicates that the two ATPase active sites of the P-glycoprotein multidrug transporter are closely associated.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Both P-glycoprotein nucleotide-binding sites are catalytically active

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Localization of the iodomycin binding site in hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Domain exchangeability between the multidrug transporter (MDR1) and phosphatidylcholine flippase (MDR2)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

A method for the determination of inorganic phosphate in the presence of labile organic phosphate and high concentrations of protein: application to lens ATPases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Myosin active-site trapping with vanadate ion

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Communication between multiple drug binding sites on P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Secondary and tertiary structure changes of reconstituted P-glycoprotein. A Fourier transform attenuated total reflection infrared spectroscopy analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M103498200

21 January 2018

Identifiers

10.1074/JBC.M103498200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11429407%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11429407%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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