(Q43560244)

English

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil (English)

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

multiple drug resistance

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

author name string

Clarke DM

2

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

language of work or name

0 references

publication date

14 February 2001

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

276

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

18

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

14972-14979

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug resistance in oncology: diagnostic and therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Positively cooperative sites for drug transport by P-glycoprotein with distinct drug specificities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Novel sulfhydryl reagents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Unraveling the mechanism of the lactose permease of Escherichia coli

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Determining the structure and mechanism of the human multidrug resistance P-glycoprotein using cysteine-scanning mutagenesis and thiol-modification techniques

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The effects of lipids and detergents on ATPase-active P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Calcium channel block by (-)devapamil is affected by the sequence environment and composition of the phenylalkylamine receptor site.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100407200

21 January 2018

Identifiers

10.1074/JBC.M100407200

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 November 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q43560244&oldid=2100789222"