(Q43717027)

26 November 2017

title

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers (English)

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26 November 2017

1

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26 November 2017

Clarke DM

2

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26 November 2017

language of work or name

English

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publication date

22 August 2001

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Journal of Biological Chemistry

26 November 2017

published in

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26 November 2017

volume

276

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26 November 2017

issue

40

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26 November 2017

page(s)

36877-36880

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

26 November 2017

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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

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HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

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Multidrug resistance in oncology: diagnostic and therapeutic approaches.

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Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

21 January 2018

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Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

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Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 January 2018

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Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence

21 January 2018

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The minimum functional unit of human P-glycoprotein appears to be a monomer.

21 January 2018

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Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 January 2018

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 January 2018

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Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

21 January 2018

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Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism

21 January 2018

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ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR.

21 January 2018

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A kinetic model for the action of a resistance efflux pump.

21 January 2018

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Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

21 January 2018

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Identification of the cyclosporin-binding site in P-glycoprotein

21 January 2018

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A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

21 January 2018

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Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

21 January 2018

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Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

21 January 2018

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The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

21 January 2018

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Global flexibility in a sensory receptor: a site-directed cross-linking approach.

21 January 2018

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A General Method for Mapping Tertiary Contacts between Amino Acid Residues in Membrane-Embedded Proteins

21 January 2018

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The aspartate receptor cytoplasmic domain: in situ chemical analysis of structure, mechanism and dynamics.

21 January 2018

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Interacting helical faces of subunits a and c in the F1Fo ATP synthase of Escherichia coli defined by disulfide cross-linking

21 January 2018

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Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

21 January 2018

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Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

21 January 2018

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DNA sequencing with chain-terminating inhibitors

21 January 2018

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Novel sulfhydryl reagents

21 January 2018

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Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

21 January 2018

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Diagnosis and reversal of multidrug resistance in paediatric cancers

21 January 2018

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The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Quantitative evaluation of the lengths of homobifunctional protein cross-linking reagents used as molecular rulers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Cross-linking of human multidrug resistance P-glycoprotein by the substrate, tris-(2-maleimidoethyl)amine, is altered by ATP hydrolysis. Evidence for rotation of a transmembrane helix.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C100467200

21 January 2018

Identifiers

DOI

10.1074/JBC.C100467200

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26 November 2017

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