(Q46593582)

23 December 2017

title

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase (English)

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23 December 2017

main subject

transmembrane protein

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3

Bart De Strooper

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23 December 2017

Alexandra Tolia

1

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23 December 2017

Katrien Horré

series ordinal

2

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23 December 2017

language of work or name

English

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publication date

15 May 2008

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23 December 2017

Journal of Biological Chemistry

published in

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23 December 2017

volume

283

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23 December 2017

issue

28

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23 December 2017

page(s)

19793-19803

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23 December 2017

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

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Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry

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Structure of a site-2 protease family intramembrane metalloprotease

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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Reconstitution of gamma-secretase activity

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

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Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

21 January 2018

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PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Gamma-secretase: proteasome of the membrane?

21 January 2018

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

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Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

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DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

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Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

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Mechanisms of drug/H+ antiport: complete cysteine-scanning mutagenesis and the protein engineering approach

21 January 2018

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The kamikaze approach to membrane transport

21 January 2018

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Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

21 January 2018

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The principle of gating charge movement in a voltage-dependent K+ channel

21 January 2018

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Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

21 January 2018

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Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

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A nine-transmembrane domain topology for presenilin 1

21 January 2018

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Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway

21 January 2018

1 reference

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

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Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

21 January 2018

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Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes

21 January 2018

1 reference

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C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation

21 January 2018

1 reference

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Force-dependent chemical kinetics of disulfide bond reduction observed with single-molecule techniques

21 January 2018

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Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

21 January 2018

1 reference

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices

21 January 2018

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Identification of gamma-secretase inhibitor potency determinants on presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Transmembrane domain II of the Na+/proline transporter PutP of Escherichia coli forms part of a conformationally flexible, cytoplasmic exposed aqueous cavity within the membrane

21 January 2018

1 reference

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Proline-induced distortions of transmembrane helices.

21 January 2018

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Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Enzymatic analysis of a rhomboid intramembrane protease implicates transmembrane helix 5 as the lateral substrate gate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M802461200

21 January 2018

Identifiers

DOI

10.1074/JBC.M802461200

1 reference

23 December 2017

1 reference

23 December 2017