(Q40667534)

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Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding.

scientific article published on 27 February 2003

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scholarly article

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31 October 2019

Substrate-induced conformational changes in the transmembrane segments of human P-glycoprotein. Direct evidence for the substrate-induced fit mechanism for drug binding (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12609990%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

transmembrane protein

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1

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31 October 2019

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M Claire Bartlett

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31 October 2019

David M Clarke

3

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31 October 2019

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27 February 2003

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31 October 2019

Journal of Biological Chemistry

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31 October 2019

278

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31 October 2019

16

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31 October 2019

13603-13606

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31 October 2019

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

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21 January 2018

Mammalian ABC transporters in health and disease

1 reference

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21 January 2018

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

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21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

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21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

The minimum functional unit of human P-glycoprotein appears to be a monomer.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

The transmembrane domains of the human multidrug resistance P-glycoprotein are sufficient to mediate drug binding and trafficking to the cell surface.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

Superfolding of the partially unfolded core-glycosylated intermediate of human P-glycoprotein into the mature enzyme is promoted by substrate-induced transmembrane domain interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil

1 reference

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21 January 2018

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

1 reference

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21 January 2018

Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein.

1 reference

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21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

The packing of the transmembrane segments of human multidrug resistance P-glycoprotein is revealed by disulfide cross-linking analysis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

Multidrug resistance after retroviral transfer of the human MDR1 gene correlates with P-glycoprotein density in the plasma membrane and is not affected by cytotoxic selection

1 reference

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21 January 2018

Drug binding in human P-glycoprotein causes conformational changes in both nucleotide-binding domains.

1 reference

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21 January 2018

A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.

1 reference

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21 January 2018

Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport

1 reference

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21 January 2018

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

1 reference

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21 January 2018

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

1 reference

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21 January 2018

Relation between the turnover number for vinblastine transport and for vinblastine-stimulated ATP hydrolysis by human P-glycoprotein

1 reference

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21 January 2018

Search for specific inhibitors of multidrug resistance in cancer

1 reference

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21 January 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

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21 January 2018

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

1 reference

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21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

Identification of Residues within the Drug-binding Domain of the Human Multidrug Resistance P-glycoprotein by Cysteine-scanning Mutagenesis and Reaction with Dibromobimane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

Drug-stimulated ATPase Activity of Human P-glycoprotein Requires Movement between Transmembrane Segments 6 and 12

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300073200

21 January 2018

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

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21 January 2018

Identifiers

10.1074/JBC.C300073200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12609990%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12609990%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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