(Q40943018)

25 September 2017

title

Identification of P-glycoprotein mutations causing a loss of steroid recognition and transport (English)

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25 September 2017

Vo QD

1

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25 September 2017

Gruol DJ

series ordinal

2

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25 September 2017

language of work or name

English

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publication date

1 July 1999

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Journal of Biological Chemistry

25 September 2017

published in

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25 September 2017

volume

274

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25 September 2017

issue

29

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25 September 2017

page(s)

20318-20327

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Steroid treatment, accumulation, and antagonism of P-glycoprotein in multidrug-resistant cells.

25 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Functional analysis of P-glycoprotein mutants identifies predicted transmembrane domain 11 as a putative drug binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Genetic analysis of the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Modulatory effects on substrate specificity of independent mutations at the serine939/941 position in predicted transmembrane domain 11 of P-glycoproteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Characterization of the human multidrug resistance protein containing mutations in the ATP-binding cassette signature region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Contribution to substrate specificity and transport of nonconserved residues in transmembrane domain 12 of human P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Mutational analysis of human P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Molecular basis of preferential resistance to colchicine in multidrug-resistant human cells conferred by Gly-185----Val-185 substitution in P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Phenothiazines cause a shift in the cAMP dose-response: Selection of resistant variants in a murine thymoma line

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in murine T-lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Activation of the mouse mdr3 gene by insertion of retroviruses in multidrug-resistant P388 tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Identification of the domains of photoincorporation of the 3'- and 7-benzophenone analogues of taxol in the carboxyl-terminal half of murine mdr1b P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Mutational Analysis of the Predicted First Transmembrane Segment of Each Homologous Half of Human P-glycoprotein Suggests That They Are Symmetrically Arranged in the Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Identification of Residues in the Drug-binding Site of Human P-glycoprotein Using a Thiol-reactive Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

Alteration of Substrate Specificity by Mutations at the His61Position in Predicted Transmembrane Domain 1 of Human MDR1/P-Glycoprotein†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.29.20318

21 January 2018

Identifiers

DOI

10.1074/JBC.274.29.20318

1 reference

25 September 2017

1 reference