(Q43610789)

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Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

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Europe PubMed Central

PubMed publication ID

25 November 2017

Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Marc-Étienne Rousseau

5

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

author name string

Urbatsch IL

1

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Gimi K

2

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Wilke-Mounts S

3

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Lerner-Marmarosh N

4

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Gros P

6

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Senior AE

7

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

language of work or name

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publication date

16 May 2001

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

25 November 2017

276

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

29

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

26980-26987

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Biochemistry of multidrug resistance mediated by the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

The P-glycoprotein efflux pump: how does it transport drugs?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Identification of the cyclosporin-binding site in P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

The catalytic cycle of P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

P-glycoprotein shows strong catalytic cooperativity between the two nucleotide sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Membrane topology of a cysteine-less mutant of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

The vacuolar H+-ATPase of clathrin-coated vesicles is reversibly inhibited by S-nitrosoglutathione

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Mechanism of action of human P-glycoprotein ATPase activity. Photochemical cleavage during a catalytic transition state using orthovanadate reveals cross-talk between the two ATP sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Use of chemical chaperones in the yeast Saccharomyces cerevisiae to enhance heterologous membrane protein expression: high-yield expression and purification of human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Rapid purification of human P-glycoprotein mutants expressed transiently in HEK 293 cells by nickel-chelate chromatography and characterization of their drug-stimulated ATPase activities.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

The anatomy and taxonomy of protein structure

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Crystal structure of the ATP-binding subunit of an ABC transporter

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Identification of Residues in the Drug-binding Domain of Human P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Iodomycin and iodipine, a structural analogue of azidopine, bind to a common domain in hamster P-glycoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Both P-glycoprotein Nucleotide-binding Sites Are Catalytically Active

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Inhibition of P-glycoprotein ATPase activity by beryllium fluoride

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Drug-stimulated nucleotide trapping in the human multidrug transporter MDR1. Cooperation of the nucleotide binding domains

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Mutations in the CYS4 gene provide evidence for regulation of the yeast vacuolar H+-ATPase by oxidation and reduction in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

High-level expression of mouse Mdr3 P-glycoprotein in yeast Pichia pastoris and characterization of ATPase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M010829200

21 January 2018

Identifiers

10.1074/JBC.M010829200

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

ResearchGate publication ID

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