(Q40472890)

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Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions.

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scholarly article

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Europe PubMed Central

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20 September 2017

Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions. (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

8

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Europe PubMed Central

PubMed publication ID

20 September 2017

author name string

Manabu Niimura

1

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Europe PubMed Central

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20 September 2017

Noriko Isoo

2

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Europe PubMed Central

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20 September 2017

Nobumasa Takasugi

3

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Europe PubMed Central

PubMed publication ID

20 September 2017

Makiko Tsuruoka

4

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Kumiko Ui-Tei

5

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Europe PubMed Central

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20 September 2017

Kaoru Saigo

6

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

Yuichi Morohashi

7

1 reference

Europe PubMed Central

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20 September 2017

Takeshi Iwatsubo

9

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Europe PubMed Central

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20 September 2017

language of work or name

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publication date

11 January 2005

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Europe PubMed Central

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20 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

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20 September 2017

280

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Europe PubMed Central

PubMed publication ID

20 September 2017

13

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Europe PubMed Central

PubMed publication ID

20 September 2017

12967-12975

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Europe PubMed Central

PubMed publication ID

20 September 2017

Therapeutic strategies for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Gamma-secretase: proteasome of the membrane?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Endoproteolytic processing and stabilization of wild-type and mutant presenilin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Evidence for phosphorylation and oligomeric assembly of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Purification and characterization of the human gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Comprehensive comparison of six microarray technologies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Exon-specific RNAi: a tool for dissecting the functional relevance of alternative splicing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The GxxxG motif: a framework for transmembrane helix-helix association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Sequence motifs, polar interactions and conformational changes in helical membrane proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

TOXCAT: a measure of transmembrane helix association in a biological membrane

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Characterization of Drosophila Presenilin and its colocalization with Notch during development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Gamma-secretase activity is associated with a conformational change of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Gamma-secretase complex assembly within the early secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Motifs of serine and threonine can drive association of transmembrane helices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Sequence context strongly modulates association of polar residues in transmembrane helices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M409829200

21 January 2018

Identifiers

10.1074/JBC.M409829200

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 September 2017

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