(Q40663039)

22 September 2017

title

Gamma-secretase activity is associated with a conformational change of nicastrin (English)

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22 September 2017

6

Christian Haass

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Dieter Edbauer

series ordinal

2

object named as

Dieter Edbauer

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22 September 2017

3

Anja Capell

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22 September 2017

Keiro Shirotani

1

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22 September 2017

Julia Schmitz

series ordinal

4

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22 September 2017

Harald Steiner

series ordinal

5

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22 September 2017

language of work or name

English

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publication date

18 March 2003

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Journal of Biological Chemistry

22 September 2017

published in

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22 September 2017

volume

278

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22 September 2017

issue

19

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22 September 2017

page(s)

16474-16477

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Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

22 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C300095200

21 January 2018

Identifiers

DOI

10.1074/JBC.C300095200

1 reference

22 September 2017

1 reference