(Q28285387)

1

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Ye Ingrid Yin

2

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Yue-Ming Li

3

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Sangram S Sisodia

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

19 November 2004

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published in

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volume

279

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issue

47

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page(s)

48615-9

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cites work

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400396200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400396200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400396200

Reconstitution of gamma-secretase activity

21 January 2018

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Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2.

21 January 2018

1 reference

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400396200

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

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PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

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Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

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Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

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Coatomer interaction with di-lysine endoplasmic reticulum retention motifs

21 January 2018

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Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

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The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.

21 January 2018

1 reference

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Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

21 January 2018

1 reference

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

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Presenilins are not required for A beta 42 production in the early secretory pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400396200

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400396200

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400396200