(Q40620892)

22 September 2017

Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex (English)

1 reference

22 September 2017

Membrane Topology and Nicastrin-enhanced Endoproteolysis of APH-1, a Component of the γ-Secretase Complex (English)

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

27 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

27 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

27 March 2024

2

Adam S. Crystal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14593096

27 March 2024

Vanessa Alexandra Morais

3

object named as

Vanessa A. Morais

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14593096

27 March 2024

author name string

Virginia M-Y Lee

5

1 reference

22 September 2017

Ryan R. Fortna

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14593096

27 March 2024

Donald S. Pijak

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14593096

27 March 2024

Robert W. Doms

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14593096

27 March 2024

language of work or name

English

0 references

publication date

30 October 2003

1 reference

full work available at URL

22 September 2017

http://www.jbc.org/article/S0021925820751707/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14593096

https://api.elsevier.com/content/article/PII:S0021925820751707?httpAccept=text/xml

27 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

https://api.elsevier.com/content/article/PII:S0021925820751707?httpAccept=text/plain

27 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

https://syndication.highwire.org/content/doi/10.1074/jbc.M310505200

27 March 2024

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

Journal of Biological Chemistry

27 March 2024

published in

1 reference

22 September 2017

279

1 reference

22 September 2017

3685-3693

1 reference

22 September 2017

5

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

22 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Intramembrane proteolysis by presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Amyloid plaque core protein in Alzheimer disease and Down syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Membrane topology of gamma-secretase component PEN-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Assembly of asparagine-linked oligosaccharides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Subcellular distribution and membrane topology of the mammalian concentrative Na+-nucleoside cotransporter rCNT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Drosophila nicastrin is essential for the intramembranous cleavage of notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

The molecular biology of leukocyte chemoattractant receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M310505200

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

21 January 2018

36

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

Protein topology of presenilin 1

27 March 2024

38

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

Membrane topology of the C. elegans SEL-12 presenilin

27 March 2024

39

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

Substitution of charged amino acid residues in transmembrane regions 6 and 7 affect ligand binding and signal transduction of the prostaglandin EP3 receptor

27 March 2024

42

1 reference

https://api.crossref.org/works/10.1074/JBC.M310505200

27 March 2024

Identifiers

1 reference

release_uiigjgge3rgmzkb2dd26me4piy

22 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uiigjgge3rgmzkb2dd26me4piy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference