(Q28610905)

English

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

scientific article published on April 15, 2003

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scholarly article

1 reference

3 February 2017

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals (English)

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals (English)

1 reference

10.1523/JNEUROSCI.23-08-03272.2003

https://api.crossref.org/works/10.1523/JNEUROSCI.23-08-03272.2003

28 December 2023

author name string

Tong Li

1

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

Guojun Ma

2

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

Huaibin Cai

3

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

Donald L. Price

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716934

28 December 2023

Philip C. Wong

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716934

28 December 2023

language of work or name

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publication date

15 April 2003

1 reference

3 February 2017

full work available at URL

https://www.jneurosci.org/content/jneuro/23/8/3272.full.pdf

Portable Document Format

online access status

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716934

28 December 2023

http://www.jneurosci.org/cgi/content/abstract/23/8/3272

online access status

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716934

28 December 2023

https://europepmc.org/articles/PMC6742329

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716934

28 December 2023

https://europepmc.org/articles/PMC6742329?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716934

28 December 2023

https://doi.org/10.1523/jneurosci.23-08-03272.2003

online access status

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12716934

28 December 2023

https://syndication.highwire.org/content/doi/10.1523/JNEUROSCI.23-08-03272.2003

1 reference

10.1523/JNEUROSCI.23-08-03272.2003

https://api.crossref.org/works/10.1523/JNEUROSCI.23-08-03272.2003

28 December 2023

Journal of Neuroscience

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

23

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

3272-3277

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

8

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin binds to membrane-tethered Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drosophila nicastrin is essential for the intramembranous cleavage of notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetically engineered mouse models of neurodegenerative diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch1 is required for the coordinate segmentation of somites

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch1 is essential for postimplantation development in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12716934

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.23-08-03272.2003

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6742329&resulttype=core&format=json

12 May 2020

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