(Q40068858)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

title

Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology (English)

1 reference

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8 January 2020

1 reference

7

1 reference

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8 January 2020

author name string

Lawrence G Iben

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Richard E Olson

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Lynn A Balanda

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Sukhanya Jayachandra

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Barbara J Robertson

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Vanessa Hay

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

C V C Prasad

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Robert Zaczek

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Charles F Albright

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

Jeremy H Toyn

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

language of work or name

English

0 references

publication date

11 October 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

8 January 2020

number of pages

8

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

8 January 2020

volume

282

1 reference

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8 January 2020

issue

51

1 reference

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8 January 2020

page(s)

36829-36836

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

Identification of a novel family of presenilin homologues

8 January 2020

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

21 January 2018

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

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Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Purification and characterization of the human gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Identification of signal peptide peptidase, a presenilin-type aspartic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Dynamics of {beta}-amyloid reductions in brain, cerebrospinal fluid, and plasma of {beta}-amyloid precursor protein transgenic mice treated with a {gamma}-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Al

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Signal peptide of eosinophil cationic protein is toxic to cells lacking signal peptide peptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Gamma-secretase inhibitors for Alzheimer's disease: balancing efficacy and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

Signal sequences: more than just greasy peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M707002200

21 January 2018

Identifiers

DOI

10.1074/JBC.M707002200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17932033%20AND%20SRC:MED&resulttype=core&format=json

release_pcn3iobcsncytcb4jfhpbuceau

8 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pcn3iobcsncytcb4jfhpbuceau

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference