(Q44814697)

6 December 2017

Binding sites of gamma-secretase inhibitors in rodent brain: distribution, postnatal development, and effect of deafferentation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

author name string

Xiao-Xin Yan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

Tong Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

Cynthia M Rominger

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

Shimoga R Prakash

4

1 reference

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12 May 2020

Philip C Wong

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

Richard E Olson

6

1 reference

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12 May 2020

Robert Zaczek

7

1 reference

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12 May 2020

Yu-Wen Li

8

1 reference

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12 May 2020

language of work or name

English

0 references

publication date

1 March 2004

1 reference

6 December 2017

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

volume

24

1 reference

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12 May 2020

issue

12

1 reference

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12 May 2020

page(s)

2942-2952

1 reference

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

12 May 2020

cites work

1 reference

12 December 2020

Neurogenesis in adulthood: a possible role in learning

1 reference

12 December 2020

Expression of presenilin 1 in nervous system during rat development.

1 reference

12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

12 December 2020

Regeneration of olfactory receptor neurons following chemical lesion: time course and enhancement with growth factor administration

1 reference

12 December 2020

Hemisynaptic distribution patterns of presenilins and beta-APP isoforms in the rodent cerebellum and hippocampus

1 reference

12 December 2020

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

12 December 2020

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

1 reference

12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

12 December 2020

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

12 December 2020

Presenilin is required for proper morphology and function of neurons in C. elegans

1 reference

12 December 2020

Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization

1 reference

12 December 2020

Olfactory centres in Alzheimer's disease: olfactory bulb is involved in early Braak's stages.

1 reference

12 December 2020

Alzheimer's disease: genes, proteins, and therapy

1 reference

12 December 2020

Cerebellar neurocognition: a new avenue.

1 reference

12 December 2020

Spatial long-term memory is related to mossy fiber synaptogenesis.

1 reference

12 December 2020

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

1 reference

12 December 2020

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

12 December 2020

Ultrastructural analysis of climbing fiber-Purkinje cell synaptogenesis in the rat cerebellum.

1 reference

12 December 2020

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

1 reference

12 December 2020

Presenilin-dependent gamma-secretase activity modulates neurite outgrowth

1 reference

12 December 2020

Postnatal maturation of Na+, K+, 2Cl- cotransporter expression and inhibitory synaptogenesis in the rat hippocampus: an immunocytochemical analysis

1 reference

12 December 2020

Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory.

1 reference

12 December 2020

Functional anatomy of thalamus and basal ganglia

1 reference

12 December 2020

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

1 reference

12 December 2020

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

12 December 2020

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

12 December 2020

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors

1 reference

12 December 2020

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

12 December 2020

An autoradiographic analysis of histogenesis in the mouse cerebellum

1 reference

12 December 2020

Regulatory roles of presenilin-1 and nicastrin in neuronal differentiation during in vitro neurogenesis

1 reference

12 December 2020

Maturation of rat visual cortex. III. Postnatal morphogenesis and synaptogenesis of local circuit neurons.

1 reference

12 December 2020

Immunocytochemical localization of the precursor protein for beta-amyloid in the rat central nervous system

1 reference

12 December 2020

Postnatal development of axosomatic synapses in the rat visual cortex: morphogenesis and quantitative evaluation.

1 reference

12 December 2020

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

1 reference

12 December 2020

Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life

1 reference

12 December 2020

Development of the hippocampal region in the rat. II. Morphogenesis during embryonic and early postnatal life.

1 reference

12 December 2020

Neurogenesis and cell death in olfactory epithelium

1 reference

12 December 2020

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

12 December 2020

Building action repertoires: memory and learning functions of the basal ganglia

1 reference

12 December 2020

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1 reference

12 December 2020

Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

1 reference

12 December 2020

Immunohistochemical analysis of presenilin-1 expression in the mouse brain.

1 reference

12 December 2020

In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain

1 reference

12 December 2020

Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains.

1 reference

12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

12 December 2020

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1 reference

12 December 2020

Immunoreactivity of presenilin-1 in human, rat and mouse brain.

1 reference

12 December 2020

Immunohistochemical analysis of presenilin 2 expression in the mouse brain: distribution pattern and co-localization with presenilin 1 protein

1 reference

12 December 2020

The role of amyloid in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

Evolution of neuronal changes in the course of Alzheimer's disease.

1 reference

12 December 2020

Presenilin-1 mRNA and beta-amyloid precursor protein mRNA are expressed in the developing rat olfactory and vestibulocochlear systems.

1 reference

12 December 2020

10.1523/JNEUROSCI.0092-04.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729845&resulttype=core&format=json

12 May 2020

1 reference