(Q21122090)

English

Signal peptide peptidase like 2C

mammalian protein found in Homo sapiens

SPPL2C
IMP-5
signal peptide peptidase-like 2C
SPP-like 2C
intramembrane protease 5

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Statements

1 reference

13 November 2019

Signal peptide peptidase-like 2C

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8IUH8

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IEA

protein homodimerization activity

1 reference

8 April 2019

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IEA

aspartic-type endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IEA

aspartic endopeptidase activity, intramembrane cleaving

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IBA

cell component

integral component of cytoplasmic side of endoplasmic reticulum membrane

1 reference

27 March 2018

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUH8&geneProductId=UniProtKB:Q8IUH8

determination method

IDA

integral component of lumenal side of endoplasmic reticulum membrane

1 reference

27 March 2018

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUH8&geneProductId=UniProtKB:Q8IUH8

determination method

IDA

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IBA

Golgi-associated vesicle membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IBA

integral component of cytoplasmic side of endoplasmic reticulum membrane

determination method

IBA

IDA

integral component of lumenal side of endoplasmic reticulum membrane

membrane protein intracellular domain proteolysis

1 reference

8 April 2019

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IMP

membrane protein ectodomain proteolysis

1 reference

8 April 2019

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IEA

membrane protein proteolysis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUH8

determination method

IBA

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

(Q21122090)

Signal peptide peptidase like 2C

Statements

Identifiers

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