(Q21126381)

http://www.ebi.ac.uk/interpro/protein/Q8TCT8

Presenilin ER Ca2+ Leak Channel

1 reference

Transporter Classification Database ID

1.A.54.3.2

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

PA domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

protein homodimerization activity

1 reference

8 April 2019

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

aspartic-type endopeptidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

3 references

8 April 2019

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

aspartic endopeptidase activity, intramembrane cleaving

IEA

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

26 September 2017

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

aspartic endopeptidase activity, intramembrane cleaving

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

1 January 2018

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

aspartic endopeptidase activity, intramembrane cleaving

IBA

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

1 reference

8 April 2019

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

intracellular membrane-bounded organelle

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

integral component of cytoplasmic side of endoplasmic reticulum membrane

1 reference

26 September 2017

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

26 September 2017

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

Golgi-associated vesicle membrane

1 reference

26 September 2017

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

integral component of lumenal side of endoplasmic reticulum membrane

IEA

1 reference

26 September 2017

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

extracellular exosome

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

Integral and associated lysosomal membrane proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

HDA

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

integral component of cytoplasmic side of endoplasmic reticulum membrane

HDA

IBA

integral component of lumenal side of endoplasmic reticulum membrane

membrane protein proteolysis

1 reference

26 September 2017

In vivo measurements of ethanol concentration in rabbit brain by 1H magnetic resonance spectroscopy

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT8&geneProductId=UniProtKB:Q8TCT8

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

membrane protein intracellular domain proteolysis

IEA

4 references

8 April 2019

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

8 April 2019

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

regulation of tumor necrosis factor-mediated signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT8

1 reference

InterPro Release 71.0