(Q24300435)

English

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

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scholarly article

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The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion (English)

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constitutive protein ectodomain proteolysis

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Gene Ontology release 2020-05-02

Gene Ontology ID

membrane protein ectodomain proteolysis

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Gene Ontology release 2020-05-02

Gene Ontology ID

N^2^-[(2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl]-N,3-dimethyl-L-valinamide

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ChEBI release 2020-05-28

ADAM metallopeptidase domain 10

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GOA release 2020-03-11

TIMP metallopeptidase inhibitor 1

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GOA release 2020-03-11

C-X3-C motif chemokine ligand 1

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GOA release 2020-03-11

positive regulation of calcium-independent cell-cell adhesion

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GOA release 2020-03-11

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based on heuristic

inferred from title

5

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object named as

Andreas Ludwig

13

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Stefan Rose-John

object named as

Stefan Rose-John

12

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Karl-Josef Kallen

11

object named as

Karl-Josef Kallen

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author name string

Christian Hundhausen

1

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Dominika Misztela

2

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Theo A Berkhout

3

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Neil Broadway

4

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Karina Reiss

6

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Dieter Hartmann

7

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Falk Fahrenholz

8

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Rolf Postina

9

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Vance Matthews

10

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language of work or name

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publication date

15 August 2003

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102

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1186-95

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4

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Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Astrocyte and endothelial cell expression of ADAM 17 (TACE) in adult human CNS.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine expression in human renal inflammation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine, a CX3C chemokine, is expressed by dendritic cells and is up-regulated upon dendritic cell maturation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of fractalkine in the recruitment of monocytes to the endothelium

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Catalytic activity of ADAM28

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

MT1-MMP on the cell surface causes focal degradation of gelatin films

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice deficient in fractalkine are less susceptible to cerebral ischemia-reperfusion injury.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNA

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Up-regulated expression of fractalkine and its receptor CX3CR1 during liver injury in humans.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

N-hydroxyformamide peptidomimetics as TACE/matrix metalloprotease inhibitors: oral activity via P1' isobutyl substitution

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular disease

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor-alpha converting enzyme

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Design of selective and soluble inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

A new class of membrane-bound chemokine with a CX3C motif

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Cellular localization of fractalkine at sites of inflammation: antigen-presenting cells in psoriasis express high levels of fractalkine

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

MIP-3alpha, MIP-3beta and fractalkine induce the locomotion and the mobilization of intracellular calcium, and activate the heterotrimeric G proteins in human natural killer cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of fractalkine and its receptor, CX3CR1, in response to ischaemia-reperfusion brain injury in the rat.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Unique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of a disintegrin-like protein in cultured human vascular cells and in vivo.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Generation and analysis of mice lacking the chemokine fractalkine

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

ADAM-mediated shedding and adhesion: a vascular perspective.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Linked Chromosome 16q13 Chemokines, Macrophage-Derived Chemokine, Fractalkine, and Thymus- and Activation-Regulated Chemokine, Are Expressed in Human Atherosclerotic Lesions

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Antigraft antibody-mediated expression of metalloproteinases on endothelial cells. Differential expression of TIMP-1 and ADAM-10 depends on antibody specificity and isotype.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Association between polymorphism in the chemokine receptor CX3CR1 and coronary vascular endothelial dysfunction and atherosclerosis

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine cleavage from neuronal membranes represents an acute event in the inflammatory response to excitotoxic brain damage

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

CX3C-chemokine, fractalkine-enhanced adhesion of THP-1 cells to endothelial cells through integrin-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2002-12-3775

7 January 2021

based on heuristic

inferred from DOI database lookup

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