Wikidata

(Q21103321)

English

Polycystin 2, transient receptor potential cation channel

mammalian protein found in Homo sapiens

  • Polycystic kidney disease 2 protein
  • polycystwin
  • polycystin-2
  • R48321
  • PKD2
  • polycystic kidney disease 2 (autosomal dominant)
  • transient receptor potential cation channel subfamily P member 2
  • autosomal dominant polycystic kidney disease type II protein
In more languages

Statements

molecular function
protein binding
determination method
IPI
17 references
retrieved
24 October 2017
stated in
Polycystin-2 interacts with troponin I, an angiogenesis inhibitor
GOA
curator
UniProt
UniProt protein ID
Q13563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Troponin I binds polycystin-L and inhibits its calcium-induced channel activation
GOA
curator
UniProt
UniProt protein ID
Q13563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2
GOA
curator
UniProt
UniProt protein ID
Q13563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Specific association of the gene product of PKD2 with the TRPC1 channel
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
retrieved
24 October 2017
stated in
PKD1 interacts with PKD2 through a probable coiled-coil domain
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IPI
cell component
endoplasmic reticulum
determination method
IEA
IDA
IMP
8 references
retrieved
24 October 2017
stated in
Polycystin 2 interacts with type I inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IMP
retrieved
24 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q13563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IEA
retrieved
24 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IEA
retrieved
24 October 2017
stated in
PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation
GOA
curator
UniProt
UniProt protein ID
Q13563
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IDA
retrieved
24 October 2017
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IDA
retrieved
24 October 2017
stated in
The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IDA
retrieved
24 October 2017
stated in
PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IDA
retrieved
24 October 2017
stated in
Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13563&geneProductId=UniProtKB:Q13563
determination method
IDA
biological process

Identifiers

 
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