Wikidata

(Q21104922)

English

UPF1 RNA helicase and ATPase

mammalian protein found in Homo sapiens

  • up-frameshift suppressor 1 homolog
  • UPF1
  • NORF1
  • hUpf1
  • delta helicase
  • yeast Upf1p homolog
  • smg-2 homolog, nonsense mediated mRNA decay factor
  • UPF1 regulator of nonsense transcripts homolog
  • regulator of nonsense transcripts 1
  • nonsense mRNA reducing factor 1
  • up-frameshift mutation 1 homolog
  • ATP-dependent helicase RENT1
In more languages

Statements

molecular function
protein binding
determination method
IPI
39 references
retrieved
8 April 2019
stated in
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Regnase-1 and Roquin regulate inflammatory mRNAs
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export.
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Interaction between Ski7p and Upf1p is required for nonsense-mediated 3'-to-5' mRNA decay in yeast
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Results of the determination of serum markers in patients with malignant melanoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Non-structural protein 1 of influenza viruses inhibits rapid mRNA degradation mediated by double-stranded RNA-binding protein, staufen1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
A UPF3-mediated regulatory switch that maintains RNA surveillance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
The human RNA surveillance factor UPF1 is required for S phase progression and genome stability
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
retrieved
8 April 2019
stated in
Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IPI
RNA binding
determination method
HDA
IBA
IDA
IEA
NAS
6 references
retrieved
8 April 2019
stated in
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IEA
retrieved
8 April 2019
stated in
MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IBA
retrieved
8 April 2019
stated in
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
HDA
retrieved
8 April 2019
stated in
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
HDA
cell component
biological process
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
determination method
IEA
NAS
IDA
IMP
TAS
7 references
retrieved
17 October 2017
stated in
Mammalian orthologues of a yeast regulator of nonsense transcript stability
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900
determination method
TAS
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900
determination method
TAS
retrieved
17 October 2017
stated in
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900
determination method
NAS
retrieved
17 October 2017
stated in
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900
determination method
IEA
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900
determination method
IEA
retrieved
17 October 2017
stated in
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92900&geneProductId=UniProtKB:Q92900
determination method
IDA
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
determination method
IBA
IDA
IEA
IMP
NAS
TAS
8 references
retrieved
8 April 2019
stated in
Mammalian orthologues of a yeast regulator of nonsense transcript stability
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
TAS
retrieved
8 April 2019
stated in
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
NAS
retrieved
8 April 2019
stated in
NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IEA
retrieved
8 April 2019
stated in
Human INT6/eIF3e is required for nonsense-mediated mRNA decay
GOA
curator
UniProt
UniProt protein ID
Q92900
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92900
determination method
IBA

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21104922&oldid=2022922957"