Wikidata

(Q21106974)

English

PML nuclear body scaffold

mammalian protein found in Homo sapiens

  • promyelocytic leukemia, inducer of
  • protein PML
  • PML/RARA fusion
  • probable transcription factor PML
  • PML
  • RING finger protein 71
  • tripartite motif protein TRIM19
  • promyelocytic leukemia protein
  • tripartite motif-containing protein 19
In more languages

Statements

molecular function
protein binding
determination method
IPI
43 references
retrieved
8 April 2019
stated in
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Myeloid Elf-1-like factor, an ETS transcription factor, up-regulates lysozyme transcription in epithelial cells through interaction with promyelocytic leukemia protein
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies.
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
PML regulates PER2 nuclear localization and circadian function
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Structural and functional characterization of the phosphorylation-dependent interaction between PML and SUMO1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-beta signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Promyelocytic leukemia isoform IV confers resistance to encephalomyocarditis virus via the sequestration of 3D polymerase in nuclear bodies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Daxx Silencing Sensitizes Cells to Multiple Apoptotic Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Moloney murine leukemia virus integrase and reverse transcriptase interact with PML proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
An extended consensus motif enhances the specificity of substrate modification by SUMO
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
PML Recruits TET2 to Regulate DNA Modification and Cell Proliferation in Response to Chemotherapeutic Agent.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
A CK2-dependent mechanism for degradation of the PML tumor suppressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
retrieved
8 April 2019
stated in
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IPI
cell component
PML body
determination method
IDA
TAS
IEA
15 references
retrieved
21 June 2018
stated in
Cellular localization, expression, and structure of the nuclear dot protein 52
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
TAS
retrieved
21 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IEA
retrieved
21 June 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IEA
retrieved
21 June 2018
stated in
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
PML promotes MHC class II gene expression by stabilizing the class II transactivator
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
The mechanisms of PML-nuclear body formation
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
The tripartite motif family identifies cell compartments
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
21 June 2018
stated in
Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P29590&geneProductId=UniProtKB:P29590
determination method
IDA
PML body
determination method
IBA
IDA
IEA
TAS
15 references
retrieved
8 April 2019
stated in
Cellular localization, expression, and structure of the nuclear dot protein 52
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IEA
retrieved
8 April 2019
stated in
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
PML promotes MHC class II gene expression by stabilizing the class II transactivator
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
The tripartite motif family identifies cell compartments
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
The mechanisms of PML-nuclear body formation
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells
GOA
curator
UniProt
UniProt protein ID
P29590
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
ZIP kinase triggers apoptosis from nuclear PML oncogenic domains
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29590
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
D000071156
subject named as
Promyelocytic Leukemia Protein
0 references
MeSH tree code
D12.776.624.776.654
0 references
D12.776.660.745
0 references
D12.776.930.713
0 references
D12.776.934.500
0 references
Ensembl protein ID
 
edit
    edit
      edit
        edit
          edit
            edit
              edit
                edit
                  edit
                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21106974&oldid=2022929369"