(Q21107304)

PIN-like domain superfamily

1 reference

DNA/RNA-binding domain, Est1-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

PIN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Telomerase activating protein Est1 family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

1 reference

8 April 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

1 reference

8 April 2019

DNA polymerase binding

protein binding

3 references

8 April 2019

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Functional conservation of the telomerase protein Est1p in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

nuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

1 reference

8 April 2019

endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

1 reference

8 April 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

1 reference

8 April 2019

telomerase RNA binding

endoribonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

3 references

10 September 2018

10 September 2018

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

10 September 2018

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

RNA binding

1 reference

8 April 2019

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

ribonucleoprotein complex binding

ribonuclease activity

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

telomeric DNA binding

Functional conservation of the telomerase protein Est1p in humans

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

ribonucleoprotein complex binding

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

telomerase RNA binding

An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

endoribonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

4 references

8 April 2019

8 April 2019

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

8 April 2019

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

exon-exon junction complex

1 reference

8 April 2019

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

1 reference

8 April 2019

telomere

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

1 reference

8 April 2019

telomerase catalytic core complex

1 reference

27 March 2018

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

8 April 2019

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

telomerase holoenzyme complex

1 reference

27 March 2018

Functional conservation of the telomerase protein Est1p in humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

3 references

8 April 2019

8 April 2019

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

nucleic acid phosphodiester bond hydrolysis

biological process

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

mRNA export from nucleus

1 reference

8 April 2019

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

negative regulation of telomere capping

1 reference

8 April 2019

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

regulation of dephosphorylation

1 reference

8 April 2019

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

6 references

27 March 2018

27 March 2018

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

27 March 2018

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

27 March 2018

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

27 March 2018

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

27 March 2018

RNA phosphodiester bond hydrolysis, endonucleolytic

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

regulation of RNA stability

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

regulation of telomere maintenance via telomerase

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain

2 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

10 September 2018

The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

regulation of telomerase activity

1 reference

8 April 2019

The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

7 references

8 April 2019

8 April 2019

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

telomere maintenance via telomerase

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

RNA phosphodiester bond hydrolysis

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86US8&geneProductId=UniProtKB:Q86US8

regulation of telomere maintenance via telomerase

Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86US8

DNA/RNA-binding domain, Est1-type

has part(s)

1 reference

PIN domain

1 reference

Telomerase activating protein Est1

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016