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Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
title
Regulation of cellular immortalization and steady-state levels of the telomerase reverse transcriptase through its carboxy-terminal domain
(English)
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
main subject
Telomerase reverse transcriptase
1 reference
stated in
GOA release 2020-03-11
SMG6 nonsense mediated mRNA decay factor
1 reference
stated in
GOA release 2020-03-11
SMG5 nonsense mediated mRNA decay factor
1 reference
stated in
GOA release 2020-03-11
regulation of telomere maintenance via telomerase
1 reference
stated in
GOA release 2020-03-11
Telomerase reverse transcriptase
1 reference
stated in
GOA release 2020-03-11
author
Steven E Artandi
series ordinal
5
object named as
Steven E. Artandi
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
author name string
Elaine J. Middleman
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
Jinkuk Choi
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
Andrew S. Venteicher
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
Peggie Cheung
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
language of work or name
English
0 references
publication date
1 March 2006
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
published in
Molecular and Cellular Biology
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
volume
26
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
issue
6
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stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
page(s)
2146–2159
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stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
describes a project that uses
ImageJ
1 reference
stated in
Europe PubMed Central
retrieved
11 June 2022
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1430280/fullTextXML
based on heuristic
inferred from PubMed Central ID database lookup
cites work
Human telomerase contains two cooperating telomerase RNA molecules
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Functional conservation of the telomerase protein Est1p in humans
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Extension of life-span by introduction of telomerase into normal human cells
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
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PubMed Central
reference URL
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20 March 2017
Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1
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20 March 2017
Human telomerase contains evolutionarily conserved catalytic and structural subunits
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Specific association of human telomerase activity with immortal cells and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
A mutant with a defect in telomere elongation leads to senescence in yeast
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Reconstitution of human telomerase activity in vitro
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Shelterin: the protein complex that shapes and safeguards human telomeres
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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20 March 2017
Telomeres shorten during ageing of human fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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7 April 2017
A DNA damage checkpoint response in telomere-initiated senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
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7 April 2017
Switching and signaling at the telomere
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
7 April 2017
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
7 April 2017
Telomerase catalytic subunit homologs from fission yeast and human
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
7 April 2017
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
7 April 2017
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
7 April 2017
Protection of mammalian telomeres
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
7 April 2017
Reverse transcriptase motifs in the catalytic subunit of telomerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
7 April 2017
Two purified domains of telomerase reverse transcriptase reconstitute sequence-specific interactions with RNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Human telomerase reverse transcriptase motifs required for elongation of a telomeric substrate.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Telomere replication: an Est fest
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
A role for a novel 'trans-pseudoknot' RNA-RNA interaction in the functional dimerization of human telomerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Putative Telomere-Recruiting Domain in the Catalytic Subunit of Human Telomerase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Telomerase: biochemical considerations for enzyme and substrate.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Telomerase in the human organism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Telomerase and differentiation in multicellular organisms: turn it off, turn it on, and turn it off again
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Two independent regions of human telomerase reverse transcriptase are important for its oligomerization and telomerase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Functional multimerization of the human telomerase reverse transcriptase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Human telomerase RNA-protein interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
RNA binding domain of telomerase reverse transcriptase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Specific telomerase RNA residues distant from the template are essential for telomerase function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Functionally interacting telomerase RNAs in the yeast telomerase complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Heterogeneity in telomere length of human chromosomes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Telomere reduction in human colorectal carcinoma and with ageing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
29 September 2017
Regulation of telomere length by an N-terminal region of the yeast telomerase reverse transcriptase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
2 June 2018
Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
2 June 2018
Expression of TERT in early premalignant lesions and a subset of cells in normal tissues.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
2 June 2018
Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
2 June 2018
Processive utilization of the human telomerase template: lack of a requirement for template switching
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
27 November 2018
Telomerase maintains telomere structure in normal human cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
27 November 2018
Quantitation of the RNA polymerase II transcription machinery in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
27 November 2018
Telomere states and cell fates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
27 November 2018
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
27 November 2018
Telomerase activity in hematopoietic cells is associated with self-renewal potential
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1430280
retrieved
27 November 2018
Est1 and Cdc13 as comediators of telomerase access
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16507993
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A role for both RB and p53 in the regulation of human cellular senescence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16507993
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
In vivo loss of telomeric repeats with age in humans
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16507993
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Analysis of telomerase processivity: mechanistic similarity to HIV-1 reverse transcriptase and role in telomere maintenance
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16507993
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Est1p as a cell cycle-regulated activator of telomere-bound telomerase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16507993
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Functional analysis of the C-terminal extension of telomerase reverse transcriptase. A putative "thumb" domain
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/16507993
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1128/MCB.26.6.2146-2159.2006
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
PMCID
1430280
0 references
PubMed ID
16507993
1 reference
stated in
PubMed
PubMed ID
16507993
retrieved
4 January 2017
ResearchGate publication ID
7269799
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