(Q46109951)

19 December 2017

title

Processive utilization of the human telomerase template: lack of a requirement for template switching (English)

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19 December 2017

2

Elizabeth H Blackburn

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19 December 2017

Melissa A Rivera

1

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19 December 2017

language of work or name

English

0 references

publication date

27 September 2004

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19 December 2017

Journal of Biological Chemistry

published in

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19 December 2017

volume

279

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19 December 2017

issue

51

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19 December 2017

page(s)

53770-53781

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19 December 2017

Switching and signaling at the telomere

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A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase

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Altering specific telomerase RNA template residues affects active site function

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Specific RNA residue interactions required for enzymatic functions of Tetrahymena telomerase

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Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres

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Three telomerases with completely non-telomeric template replacements are catalytically active

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Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response

21 January 2018

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Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro

21 January 2018

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21 January 2018

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Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro

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Human telomerase contains two cooperating telomerase RNA molecules

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21 January 2018

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Telomerase RNAs of different ciliates have a common secondary structure and a permuted template

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A conserved secondary structure for telomerase RNA

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A conserved pseudoknot in telomerase RNA

21 January 2018

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A universal telomerase RNA core structure includes structured motifs required for binding the telomerase reverse transcriptase protein

21 January 2018

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The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Telomerase is processive

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The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

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Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility

21 January 2018

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Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability

21 January 2018

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A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

21 January 2018

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Comprehensive structure-function analysis of the core domain of human telomerase RNA.

21 January 2018

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

21 January 2018

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Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay

21 January 2018

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Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

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Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro

21 January 2018

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Block in anaphase chromosome separation caused by a telomerase template mutation.

21 January 2018

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

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Functional Evidence for an RNA Template in Telomerase

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cdc13 delivers separate complexes to the telomere for end protection and replication

21 January 2018

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21 January 2018

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21 January 2018

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

21 January 2018

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Roles for RNA in telomerase nucleotide and repeat addition processivity

21 January 2018

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Stem-loop IV of tetrahymena telomerase RNA stimulates processivity in trans

21 January 2018

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Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer

21 January 2018

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Adding to the ends: what makes telomerase processive and how important is it?

21 January 2018

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The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M407768200

A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M407768200

Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407768200

Template boundary definition in Tetrahymena telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407768200

Template boundary in a yeast telomerase specified by RNA structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407768200

A template-proximal RNA paired element contributes to Saccharomyces cerevisiae telomerase activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M407768200

Developmentally programmed healing of chromosomes by telomerase in Tetrahymena

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M407768200

CELL BIOLOGY: Enhanced: Telomere Capping--One Strand Fits All

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M407768200

Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M407768200

Telomerase primer specificity and chromosome healing

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M407768200

Boundary elements of the Tetrahymena telomerase RNA template and alignment domains

21 January 2018

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407768200

Sequence-Determined DNA Separations

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407768200

Identification of Functional Domains and Dominant Negative Mutations in Vertebrate Telomerase RNA Using anin VivoReconstitution System

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407768200

Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407768200

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M407768200

Identifiers

DOI

10.1074/JBC.M407768200

1 reference

19 December 2017

1 reference

19 December 2017