(Q21107568)

http://www.ebi.ac.uk/interpro/protein/Q04724

WD40-repeat-containing domain superfamily

1 reference

http://www.ebi.ac.uk/interpro/protein/Q04724

Groucho/transducin-like enhancer

2 references

http://www.ebi.ac.uk/interpro/protein/Q04724

http://www.ebi.ac.uk/interpro/protein/Q5T3G3

Groucho/TLE, N-terminal Q-rich domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

13 November 2019

17 September 2016

2 references

13 November 2019

30 June 2016

transcription corepressor activity

English

molecular function

transcription factor binding

IDA

2 references

8 references

8 April 2019

Six3 and Six6 activity is modulated by members of the groucho family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Molecular functions of the TLE tetramerization domain in Wnt target gene repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

identical protein binding

IPI

1 reference

8 April 2019

Molecular functions of the TLE tetramerization domain in Wnt target gene repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

1 reference

8 April 2019

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

5 references

5 June 2018

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

5 June 2018

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

5 June 2018

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

IDA

beta-catenin-TCF complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

6 references

8 April 2019

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

TLE1 is an anoikis regulator and is downregulated by Bit1 in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

transcription regulator complex

IBA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

1 reference

30 June 2016

1 reference

30 June 2016

1 reference

30 June 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5T3G3

1 reference

8 April 2019

negative regulation of Wnt signaling pathway

biological process

1 reference

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

NAS

Wnt signaling pathway

1 reference

8 April 2019

negative regulation of I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

transcription, DNA-templated

IDA

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

multicellular organism development

1 reference

8 April 2019

Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

positive regulation of gene expression

1 reference

8 April 2019

A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

animal organ morphogenesis

IMP

1 reference

8 April 2019

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

1 reference

8 April 2019

Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

negative regulation of transcription by RNA polymerase II

1 reference

27 February 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q04724&geneProductId=UniProtKB:Q04724

beta-catenin-TCF complex assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

negative regulation of canonical Wnt signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04724

physically interacts with

IBA

1 reference

https://thebiogrid.org/news/227

retrieved

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

BioGRID

Identifiers

MeSH descriptor ID

C499043

subject named as

TLE1 protein, human

0 references

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

13 November 2019

1 reference

30 June 2016

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference