Wikidata

(Q21107982)

English

Rap guanine nucleotide exchange factor 2

mammalian protein found in Homo sapiens

  • neural RAP guanine nucleotide exchange protein
  • Rap guanine nucleotide exchange factor (GEF) 2
  • cyclic nucleotide ras GEF
  • ras/Rap1-associating GEF-1
  • PDZ domain-containing guanine nucleotide exchange factor 1
  • rap guanine nucleotide exchange factor 2
  • CNrasGEF
  • PDZ domain containing guanine nucleotide exchange factor (GEF) 1
  • PDZ-GEF1
  • RA-GEF-1
  • RAPGEF2
  • nRap GEP
  • RA(Ras/Rap1A-associating)-GEF
In more languages
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
8 references
retrieved
8 April 2019
stated in
Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
retrieved
8 April 2019
stated in
Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
retrieved
8 April 2019
stated in
nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
retrieved
8 April 2019
stated in
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
retrieved
8 April 2019
stated in
RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
retrieved
8 April 2019
stated in
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
retrieved
8 April 2019
stated in
Membrane-associated guanylate kinase with inverted orientation (MAGI)-1/brain angiogenesis inhibitor 1-associated protein (BAP1) as a scaffolding molecule for Rap small G protein GDP/GTP exchange protein at tight junctions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IPI
cell component
biological process
positive regulation of GTPase activity
determination method or standard
IDA
IEA
IMP
10 references
retrieved
8 April 2019
stated in
Rap2A links intestinal cell polarity to brush border formation
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IMP
retrieved
8 April 2019
stated in
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IEA
retrieved
8 April 2019
stated in
Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IDA
retrieved
8 April 2019
stated in
nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding molecule (S-SCAM)
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IDA
retrieved
8 April 2019
stated in
The guanine nucleotide exchange factor CNrasGEF regulates melanogenesis and cell survival in melanoma cells
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IDA
retrieved
8 April 2019
stated in
The guanine nucleotide exchange factor CNrasGEF activates ras in response to cAMP and cGMP
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IDA
retrieved
8 April 2019
stated in
RA-GEF-1, a guanine nucleotide exchange factor for Rap1, is activated by translocation induced by association with Rap1*GTP and enhances Rap1-dependent B-Raf activation
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IDA
retrieved
8 April 2019
stated in
Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IDA
retrieved
8 April 2019
stated in
RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans
GOA
curator
UniProt
UniProt protein ID
Q9Y4G8
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y4G8
determination method or standard
IDA

Identifiers

 
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