(Q21108503)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

transcription cis-regulatory region binding

1 reference

8 April 2019

The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

2 references

chromatin DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

4 references

8 April 2019

Protein interactions of the transcription factor Hoxa1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

Proteomic and genomic analysis of PITX2 interacting and regulating networks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

ribonucleoprotein complex binding

1 reference

5 June 2018

Proteomic and genomic analysis of PITX2 interacting and regulating networks

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

DNA-binding transcription repressor activity, RNA polymerase II-specific

IC

1 reference

5 June 2018

Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

transcription factor binding

1 reference

8 April 2019

Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

Proteomic and genomic analysis of PITX2 interacting and regulating networks

phosphoprotein binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

DNA-binding transcription factor activity, RNA polymerase II-specific

4 references

5 June 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

RNA polymerase II cis-regulatory region sequence-specific DNA binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

DNA-binding transcription factor activity, RNA polymerase II-specific

IBA

3 references

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

10 September 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

DNA-binding transcription factor activity, RNA polymerase II-specific

ISA

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

5 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

transcription regulator complex

IBA

1 reference

8 April 2019

Interaction, cooperative promoter modulation, and renal colocalization of GCMa and Pitx2

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

biological process

response to vitamin A

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

female gonad development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

vascular associated smooth muscle cell differentiation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

skeletal muscle tissue development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

prolactin secreting cell differentiation

1 reference

8 April 2019

Expression of the members of the Ptx family of transcription factors in human pituitary adenomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

in utero embryonic development

TAS

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

pituitary gland development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

regulation of cell population proliferation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

hair cell differentiation

1 reference

8 April 2019

Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

transcription by RNA polymerase II

IC

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

embryonic camera-type eye development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

ventricular septum morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

endodermal digestive tract morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

cardiac muscle tissue development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

positive regulation of transcription, DNA-templated

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

subthalamic nucleus development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

ventricular cardiac muscle cell development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

hypothalamus cell migration

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

animal organ morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

regulation of cell migration

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

embryonic digestive tract morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

branching involved in blood vessel morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

cardiac muscle cell differentiation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

digestive system development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

multicellular organism development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

atrioventricular valve development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

pulmonary vein morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

embryonic hindlimb morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

superior vena cava morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

positive regulation of DNA binding

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

extraocular skeletal muscle development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

pulmonary myocardium development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

atrial cardiac muscle tissue morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

male gonad development

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

anatomical structure morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

neuron differentiation

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

odontogenesis of dentin-containing tooth

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

Wnt signaling pathway

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

left lung morphogenesis

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

somatotropin secreting cell differentiation

1 reference

8 April 2019

Expression of the members of the Ptx family of transcription factors in human pituitary adenomas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

positive regulation of myoblast proliferation

TAS

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

camera-type eye development

1 reference

8 April 2019

Mutation in the RIEG1 gene in patients with iridogoniodysgenesis syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

1 reference

8 April 2019

Autosomal dominant iris hypoplasia is caused by a mutation in the Rieger syndrome (RIEG/PITX2) gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

positive regulation of transcription by RNA polymerase II

6 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

Cell-specific activation of the atrial natriuretic factor promoter by PITX2 and MEF2A

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

Proteomic and genomic analysis of PITX2 interacting and regulating networks

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

5 June 2018

Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99697&geneProductId=UniProtKB:Q99697

cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

regulation of transcription by RNA polymerase II

1 reference

8 April 2019

A model for the molecular underpinnings of tooth defects in Axenfeld-Rieger syndrome

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

determination of left/right symmetry

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

anatomical structure morphogenesis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

deltoid tuberosity development

IBA

1 reference

8 April 2019

PITX2 gain-of-function induced defects in mouse forelimb development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

1 reference

8 April 2019

Novel identification of a four-base-pair deletion mutation in PITX2 in a Rieger syndrome family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

positive regulation of transcription by RNA polymerase II

IMP

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

8 April 2019

Pitx2, a beta-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

cell proliferation involved in outflow tract morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

left/right axis specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99697

has part(s)

Homeobox, conserved site

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99697

Homeobox domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99697

OAR domain

1 reference

stated in

InterPro Release 71.0