(Q21108557)

English

Presenilin 2

mammalian protein found in Homo sapiens

PS-2
AD3LP
STM-2
Alzheimer disease 4
AD5
PSEN2
presenilin-2
E5-1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Peptidase A22A, presenilin 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49810

Presenilin ER Ca2+ Leak Channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

endopeptidase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

protein binding

determination method

4 references

8 April 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

8 April 2019

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

8 April 2019

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

8 April 2019

Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

aspartic endopeptidase activity, intramembrane cleaving

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

aspartic-type endopeptidase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

3 references

31 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

31 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

plasma membrane

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

integral component of plasma membrane

determination method

1 reference

31 October 2017

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

neuronal cell body

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

nuclear inner membrane

determination method

1 reference

8 April 2019

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

mitochondrial inner membrane

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

lysosomal membrane

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

neuromuscular junction

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

ciliary rootlet

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

dendritic shaft

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

synaptic vesicle

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

apical plasma membrane

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

protein-containing complex

determination method

1 reference

8 April 2019

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

synaptic membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

integral component of presynaptic membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

biological process

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

response to hypoxia

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

ephrin receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

positive regulation of catalytic activity

determination method

1 reference

8 April 2019

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

negative regulation of apoptotic process

determination method

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

amyloid-beta metabolic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

membrane protein ectodomain proteolysis

determination method

1 reference

31 October 2017

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49810&geneProductId=UniProtKB:P49810

determination method

membrane protein intracellular domain proteolysis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

calcium ion transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

Notch signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

Notch receptor processing, ligand-dependent

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

regulation of calcium import into the mitochondrion

determination method

1 reference

8 April 2019

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

mitochondrion-endoplasmic reticulum membrane tethering

determination method

1 reference

8 April 2019

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49810

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000355747

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355747

ENSP00000403737

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403737

ENSP00000355746

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000355746

ENSP00000427806

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427806

ENSP00000427912

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427912

ENSP00000429036

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429036

ENSP00000429682

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429682

ENSP00000486498

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486498

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

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