Wikidata

(Q21108624)

English

Platelet derived growth factor receptor beta

mammalian protein found in Homo sapiens

  • NDEL1-PDGFRB
  • beta-type platelet-derived growth factor receptor
  • PDGFR-beta
  • Activated tyrosine kinase PDGFRB
  • PDGFR-1
  • platelet-derived growth factor receptor 1
  • PDGFRB
  • platelet-derived growth factor receptor beta
  • platelet-derived growth factor receptor, beta polypeptide
  • PDGF-R-beta
  • CD140 antigen-like family member B
  • Beta platelet-derived growth factor receptor
In more languages

Statements

part of
molecular function
protein binding
determination method
IPI
59 references
retrieved
8 April 2019
stated in
NHERF1/EBP50 head-to-tail intramolecular interaction masks association with PDZ domain ligands
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Binding of GAP to activated PDGF receptors
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Structural and Thermodynamic Basis for the Interaction of the Src SH2 Domain with the Activated Form of the PDGF β-receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
In vivo binding properties of SH2 domains from GTPase-activating protein and phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Identification of protein tyrosine phosphatases associating with the PDGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Alternative modes of binding of proteins with tandem SH2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Dual specificity of Src homology 2 domains for phosphotyrosine peptide ligands
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Wild-type LRP6 inhibits, whereas atherosclerosis-linked LRP6R611C increases PDGF-dependent vascular smooth muscle cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
The BPV-1 E5 protein, the 16 kDa membrane pore-forming protein and the PDGF receptor exist in a complex that is dependent on hydrophobic transmembrane interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
NMR dynamics-derived insights into the binding properties of a peptide interacting with an SH2 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Src-like adaptor protein (Slap) is a negative regulator of mitogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
A biosensor approach to probe the structure and function of the p85 alpha subunit of the phosphatidylinositol 3-kinase complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer-derived K172N, D301V mutations abolish Na+/H+ exchanger regulatory factor 1 inhibition of platelet-derived growth factor receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Platelet-derived growth factor receptor sequences important for binding of src family tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Grb7 is a downstream signaling component of platelet-derived growth factor alpha- and beta-receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Construction of an SH2 domain-binding site with mixed specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation-dependent yeast two-hybrid system for the identification of the SH2 domain-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Direct determination of the sequence recognition requirements of the SH2 domains of SH-PTP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Correlation between dynamics and high affinity binding in an SH2 domain interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Mechanism of platelet-derived growth factor (PDGF) AA, AB, and BB binding to alpha and beta PDGF receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
A role for VEGF as a negative regulator of pericyte function and vessel maturation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of protein tyrosine phosphatase SH-PTP2. Study of phosphopeptide substrates and possible regulatory role of SH2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Structural and Functional Integration of the PLCγ Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Structure-activity studies of phosphorylated peptide inhibitors of the association of phosphatidylinositol 3-kinase with PDGF-beta receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
The 64-kDa protein that associates with the platelet-derived growth factor receptor beta subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Structural and biochemical evaluation of the interaction of the phosphatidylinositol 3-kinase p85alpha Src homology 2 domains with phosphoinositides and inositol polyphosphates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
retrieved
8 April 2019
stated in
Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IPI
platelet-derived growth factor beta-receptor activity
determination method
IDA
IEA
IMP
6 references
retrieved
31 October 2017
stated in
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09619&geneProductId=UniProtKB:P09619
determination method
IMP
retrieved
31 October 2017
stated in
Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09619&geneProductId=UniProtKB:P09619
determination method
IMP
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09619&geneProductId=UniProtKB:P09619
determination method
IEA
retrieved
31 October 2017
stated in
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09619&geneProductId=UniProtKB:P09619
determination method
IDA
retrieved
31 October 2017
stated in
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09619&geneProductId=UniProtKB:P09619
determination method
IDA
retrieved
31 October 2017
stated in
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P09619&geneProductId=UniProtKB:P09619
determination method
IDA
platelet-derived growth factor beta-receptor activity
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Independent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IMP
retrieved
8 April 2019
stated in
Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IEA
retrieved
8 April 2019
stated in
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IDA
retrieved
8 April 2019
stated in
Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
GOA
curator
UniProt
UniProt protein ID
P09619
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IDA
retrieved
8 April 2019
stated in
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P09619
determination method
IBA
cell component
biological process
physically interacts with
has part(s)

Identifiers

 
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