(Q21109248)

English

Arrestin beta 2

mammalian protein found in Homo sapiens

Arrestin beta-2
non-visual arrestin-3
arrestin 3
ARRB2
beta-arrestin-2

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32121

Arrestin, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32121

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32121

Arrestin, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32121

Arrestin C-terminal-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Arrestin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Arrestin-like, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

alpha-1B adrenergic receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

14-3-3 protein binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

protein kinase B binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

protein binding

determination method

25 references

9 May 2019

Identification of beta-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Novel function of beta-arrestin2 in the nucleus of mature spermatozoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Ubiquitination of CXCR7 controls receptor trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Carboxy-terminus of CXCR7 regulates receptor localization and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Global landscape of HIV-human protein complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Regulation of amygdalar PKA by beta-arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Functional specialization of beta-arrestin interactions revealed by proteomic analysis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

An empirical framework for binary interactome mapping

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

determination method

1 reference

9 May 2019

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

angiotensin receptor binding

determination method

1 reference

8 April 2019

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

signaling receptor binding

determination method

1 reference

9 May 2019

An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

G protein-coupled receptor binding

determination method

1 reference

8 April 2019

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

ubiquitin protein ligase binding

determination method

identical protein binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

arrestin family protein binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

protein-containing complex binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

protein domain specific binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

alpha-1A adrenergic receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

type 1 angiotensin receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

D1 dopamine receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

follicle-stimulating hormone receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

type 2A serotonin receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

platelet activating factor receptor binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

mitogen-activated protein kinase binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

G protein-coupled receptor binding

determination method

determination method

7 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

Novel function of beta-arrestin2 in the nucleus of mature spermatozoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

postsynaptic membrane

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

postsynaptic density

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

plasma membrane

determination method

3 references

9 May 2019

G protein-coupled estrogen receptor 1/G protein-coupled receptor 30 localizes in the plasma membrane and traffics intracellularly on cytokeratin intermediate filaments

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

endocytic vesicle

determination method

1 reference

9 May 2019

β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

dendritic spine

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

intracellular anatomical structure

determination method

1 reference

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32121&geneProductId=UniProtKB:P32121

determination method

basolateral plasma membrane

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

clathrin-coated pit

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

cytoplasmic vesicle

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

intracellular membrane-bounded organelle

determination method

1 reference

9 May 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

determination method

8 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Novel function of beta-arrestin2 in the nucleus of mature spermatozoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

biological process

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

9 May 2019

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of calcium ion transport

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of interleukin-1 beta production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of protein kinase B signaling

determination method

1 reference

9 May 2019

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of protein kinase B signaling

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

regulation of G protein-coupled receptor signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of release of cytochrome c from mitochondria

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of interleukin-6 production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

receptor internalization

determination method

1 reference

9 May 2019

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

transcription by RNA polymerase II

determination method

1 reference

9 May 2019

Novel function of beta-arrestin2 in the nucleus of mature spermatozoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of peptidyl-serine phosphorylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

detection of temperature stimulus involved in sensory perception of pain

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

follicle-stimulating hormone signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

platelet activation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

dopamine receptor signaling pathway

determination method

1 reference

9 May 2019

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

brain development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of GTPase activity

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of toll-like receptor signaling pathway

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

protein ubiquitination

determination method

1 reference

9 May 2019

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of DNA biosynthetic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

3 references

8 April 2019

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of peptidyl-tyrosine phosphorylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

cell chemotaxis

determination method

1 reference

9 May 2019

Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

protein transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of natural killer cell mediated cytotoxicity

determination method

1 reference

9 May 2019

An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

regulation of androgen receptor signaling pathway

determination method

1 reference

9 May 2019

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of synaptic transmission, dopaminergic

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of signal transduction

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of protein ubiquitination

determination method

1 reference

9 May 2019

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

9 May 2019

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

negative regulation of smooth muscle cell apoptotic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

signal transduction

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

adult walking behavior

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of interleukin-12 production

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

Wnt signaling pathway, planar cell polarity pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of protein phosphorylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

G protein-coupled receptor internalization

determination method

3 references

8 April 2019

Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

8 April 2019

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of gene expression

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

protein deubiquitination

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

membrane organization

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of cardiac muscle cell differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

excitatory postsynaptic potential

determination method

1 reference

9 May 2019

A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of collagen biosynthetic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

negative regulation of neuron apoptotic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of epithelial cell apoptotic process

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

G protein-coupled receptor internalization

determination method

4 references

9 May 2019

Dynamic modulation of FGFR1-5-HT1A heteroreceptor complexes. Agonist treatment enhances participation of FGFR1 and 5-HT1A homodimers and recruitment of β-arrestin2

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

4 references

9 May 2019

Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

beta-arrestin differentially regulates the chemokine receptor CXCR4-mediated signaling and receptor internalization, and this implicates multiple interaction sites between beta-arrestin and CXCR4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32121

determination method

Arrestin-like, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32121

Arrestin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32121

Arrestin C-terminal-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P32121

Identifiers

MeSH descriptor ID

subject named as

beta-Arrestin 2

0 references

D12.644.360.024.098.525.750

0 references

D12.776.157.057.005.525.750

0 references

D12.776.476.024.104.525.750

0 references

D12.776.543.090.525.750

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000269260

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000269260

ENSP00000341895

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000341895

ENSP00000370898

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000370898

ENSP00000403701

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000403701

ENSP00000458371

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458371

ENSP00000458946

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458946

ENSP00000460607

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460607

ENSP00000460879

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460879

ENSP00000465296

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465296

ENSP00000465877

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465877

ENSP00000466344

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466344

ENSP00000466857

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466857

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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