(Q21109253)

Protein kinase-like domain superfamily

1 reference

Protein kinase C, PB1 domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Protein kinase, C-terminal domain, protein family

1 reference

Atypical protein kinase C iota type, catalytic domain, protein family

1 reference

PB1 domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

protein kinase C activity

4 references

1 January 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

protein domain specific binding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

protein serine/threonine kinase activity

5 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

17 October 2017

Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

17 October 2017

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

24 references

1 January 2018

Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Network organization of the human autophagy system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Evolutionary and molecular facts link the WWC protein family to Hippo signaling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

3 references

1 January 2018

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

protein serine/threonine kinase activity

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

bicellular tight junction

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

microtubule cytoskeleton

1 reference

1 January 2018

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

2 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

Schmidt-Lanterman incisure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

apical plasma membrane

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

protein-containing complex

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

Schaffer collateral - CA1 synapse

HDA

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

glutamatergic synapse

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

negative regulation of neuron apoptotic process

biological process

1 reference

1 January 2018

Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

establishment of apical/basal cell polarity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

response to interleukin-1

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

Golgi vesicle budding

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

actin filament organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

protein targeting to membrane

1 reference

1 January 2018

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

negative regulation of glial cell apoptotic process

1 reference

1 January 2018

PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

response to peptide hormone

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

negative regulation of apoptotic process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

protein phosphorylation

3 references

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 January 2018

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

positive regulation of endothelial cell apoptotic process

1 reference

1 January 2018

Protein kinase C iota mediates lipid-induced apoptosis of human coronary artery endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

positive regulation of NF-kappaB transcription factor activity

1 reference

1 January 2018

Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

cytoskeleton organization

1 reference

1 January 2018

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

establishment or maintenance of epithelial cell apical/basal polarity

1 reference

1 January 2018

Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

bicellular tight junction assembly

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

positive regulation of neuron projection development

1 reference

1 January 2018

Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-kappaB dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

eye photoreceptor cell development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

membrane organization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

positive regulation of glial cell proliferation

1 reference

1 January 2018

PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

vesicle-mediated transport

1 reference

1 January 2018

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

cell-cell junction organization

1 reference

1 January 2018

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

peptidyl-serine phosphorylation

1 reference

17 October 2017

Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41743&geneProductId=UniProtKB:P41743

positive regulation of Notch signaling pathway

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

regulation of postsynaptic membrane neurotransmitter receptor levels

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41743

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

346

object of statement has role

English

retrieved

17 August 2016

sotrastaurin

reaction inhibitor

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL565612

gsk-690693

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL494089

has part(s)

AGC-kinase, C-terminal

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

protein kinase, C-terminal

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

PB1 domain

1 reference

serine/threonine-protein kinase, active site

1 reference

diacylglycerol/phorbol-ester binding

1 reference

Atypical protein kinase C iota type, catalytic domain

1 reference

Protein kinase C, PB1 domain

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016