(Q21109850)

Immunoglobulin-like domain superfamily

1 reference

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

CD300A.png
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0 references

1 reference

13 November 2019

1 reference

13 November 2019

phosphatidylethanolamine binding

1 reference

8 April 2019

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

phosphatidylserine binding

1 reference

8 April 2019

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

4 references

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

8 April 2019

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

8 April 2019

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

integral component of membrane

IPI

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

extracellular exosome

4 references

8 April 2019

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

8 April 2019

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

8 April 2019

CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

2 references

tertiary granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

ficolin-1-rich granule membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

regulation of T cell receptor signaling pathway

HDA

biological process

1 reference

8 April 2019

Differential expression of CD300a/c on human TH1 and TH17 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

immune system process

1 reference

8 April 2019

negative regulation of eosinophil migration

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

positive regulation of phosphoprotein phosphatase activity

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of neutrophil activation

1 reference

8 April 2019

The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of eosinophil activation

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

regulation of immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of fibroblast proliferation

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of MAP kinase activity

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of mast cell degranulation

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of mast cell activation involved in immune response

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of NK T cell activation

1 reference

8 April 2019

Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of B cell receptor signaling pathway

1 reference

8 April 2019

CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of activation of Janus kinase activity

1 reference

8 April 2019

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of phagocytosis, engulfment

1 reference

8 April 2019

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

negative regulation of B cell proliferation

IMP

1 reference

8 April 2019

CD300a is expressed on human B cells, modulates BCR-mediated signaling, and its expression is down-regulated in HIV infection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UGN4&geneProductId=UniProtKB:Q9UGN4

negative regulation of MyD88-dependent toll-like receptor signaling pathway

1 reference

8 April 2019

CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UGN4

IMP

neutrophil degranulation

1 reference

8 April 2019

immunoglobulin V-set domain

has part(s)

1 reference

immunoglobulin-like domain

1 reference

immunoglobulin subtype

1 reference