(Q21110118)

nucleotide-diphospho-sugar transferases

1 reference

Armadillo-type fold

1 reference

W2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hexapeptide repeat family

1 reference

based on heuristic

inferred from protein domain or family

Translation initiation factor eIF-2B subunit epsilon, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

18 July 2018

1 reference

18 July 2018

translation initiation factor activity

Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

27 March 2018

27 March 2018

An efficient mammalian cell-free translation system supplemented with translation factors

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

guanyl-nucleotide exchange factor activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

4 references

27 March 2018

27 March 2018

Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

27 March 2018

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

protein binding

translation initiation factor activity

IPI

Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

8 April 2019

An efficient mammalian cell-free translation system supplemented with translation factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

guanyl-nucleotide exchange factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

5 references

8 April 2019

8 April 2019

Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

translation initiation factor binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

cell component

cytoplasm

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

eukaryotic translation initiation factor 2B complex

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

27 March 2018

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

27 March 2018

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13144&geneProductId=UniProtKB:Q13144

eukaryotic translation initiation factor 2B complex

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

biological process

astrocyte development

1 reference

8 April 2019

EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

human ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

response to heat

A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

8 April 2019

EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

response to endoplasmic reticulum stress

1 reference

8 April 2019

Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

astrocyte differentiation

1 reference

8 April 2019

EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

ovarian follicle development

1 reference

8 April 2019

Screening for known mutations in EIF2Bgenes in a large panel of patients with premature ovarian failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

oligodendrocyte development

1 reference

8 April 2019

The life and death of oligodendrocytes in vanishing white matter disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

positive regulation of translational initiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

1 reference

8 April 2019

hippocampus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

response to lithium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

protein biosynthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

1 reference

8 April 2019

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

positive regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

T cell receptor signaling pathway

1 reference

8 April 2019

T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13144

1 reference

Hexapeptide repeat

1 reference

Translation initiation factor eIF-2B subunit epsilon, N-terminal

1 reference