(Q21110419)

Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains

IEA

growth factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

15 references

8 April 2019

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Protein interactions of the transcription factor Hoxa1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

A novel role for drebrin in regulating progranulin bioactivity in bladder cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

24 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799

cell component

extracellular exosome

1 reference

24 October 2017

5 references

14 January 2019

The lysosomal protein cathepsin L is a progranulin protease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799

14 January 2019

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799

14 January 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799

14 January 2019

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28799&geneProductId=UniProtKB:P28799

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

endoplasmic reticulum

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

azurophil granule lumen

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

TAS

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

The lysosomal protein cathepsin L is a progranulin protease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

1 reference

8 April 2019

Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

NAS

neutrophil degranulation

1 reference

8 April 2019

regulation of signaling receptor activity

TAS

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of cell migration

IEA

1 reference

8 April 2019

MicroRNA-588 suppresses tumor cell migration and invasion by targeting GRN in lung squamous cell carcinoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

astrocyte activation involved in immune response

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

microglial cell activation involved in immune response

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

lysosome organization

1 reference

8 April 2019

lysosomal lumen acidification

1 reference

8 April 2019

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of endothelial cell migration

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

negative regulation of neuron apoptotic process

1 reference

8 April 2019

Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of neuron apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of angiogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of axon regeneration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of epithelial cell proliferation

1 reference

8 April 2019

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo

protein stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

negative regulation of respiratory burst involved in inflammatory response

IMP

1 reference

8 April 2019

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of inflammatory response to wounding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of defense response to bacterium

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

negative regulation of neutrophil activation

1 reference

8 April 2019

Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of protein folding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

negative regulation of microglial cell activation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

positive regulation of lysosome organization

1 reference

8 April 2019

Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28799

Identifiers

MeSH descriptor ID

D000077153

subject named as

Progranulins

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30 May 2020

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30 May 2020

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13 November 2019

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9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016