Wikidata

(Q21111069)

English

Interferon induced with helicase C domain 1

mammalian protein found in Homo sapiens

  • DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
  • MDA-5
  • helicard
  • melanoma differentiation-associated protein 5
  • melanoma differentiation-associated gene 5
  • RNA helicase-DEAD box protein 116
  • clinically amyopathic dermatomyositis autoantigen 140 kDa
  • murabutide down-regulated protein
  • Interferon-induced with helicase C domain protein 1
  • IFIH1
  • helicase with 2 CARD domains
  • RLR-2
  • RIG-I-like receptor 2
  • CADM-140 autoantigen
  • interferon-induced helicase C domain-containing protein 1
  • Interferon-Induced Helicase, IFIH1
In more languages

Statements

molecular function
protein binding
determination method
IPI
18 references
retrieved
8 April 2019
stated in
MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Ankrd17 positively regulates RIG-I-like receptor (RLR)-mediated immune signaling
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner
GOA
curator
UniProt
UniProt protein ID
Q9BYX4
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Human respiratory syncytial virus nucleoprotein and inclusion bodies antagonize the innate immune response mediated by MDA5 and MAVS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
retrieved
8 April 2019
stated in
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYX4
determination method
IPI
biological process

Identifiers

MeSH descriptor ID
D000072640
subject named as
Interferon-Induced Helicase, IFIH1
0 references
Freebase ID
/m/03gz0__
0 references
 
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