(Q21111348)

RGS domain superfamily

1 reference

RGS, subdomain 1/3

1 reference

DIX domain superfamily

1 reference

DIX domain, protein family

1 reference

Axin beta-catenin binding domain, protein family

1 reference

Axin-1/2, tankyrase-binding domain, protein family

1 reference

regulator of G protein signalling

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

GTPase activator activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2T1&geneProductId=UniProtKB:Q9Y2T1

1 reference

24 April 2018

IBA

protein binding

6 references

8 April 2019

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

enzyme binding

3 references

8 April 2019

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

beta-catenin binding

1 reference

8 April 2019

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

1 reference

8 April 2019

TAS

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2T1&geneProductId=UniProtKB:Q9Y2T1

1 reference

24 April 2018

IBA

nucleus

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

IDA

8 April 2019

Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

beta-catenin destruction complex

IDA

1 reference

8 April 2019

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

regulation of mismatch repair

biological process

1 reference

8 April 2019

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

somitogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

bone mineralization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

positive regulation of protein phosphorylation

1 reference

8 April 2019

Conductin/axin2 and Wnt signalling regulates centrosome cohesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

positive regulation of cell death

1 reference

8 April 2019

Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

positive regulation of canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

1 reference

8 April 2019

positive regulation of epithelial to mesenchymal transition

TAS

1 reference

8 April 2019

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

1 reference

8 April 2019

mRNA stabilization

1 reference

8 April 2019

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

maintenance of DNA repeat elements

1 reference

8 April 2019

Frameshift mutations of Wnt pathway genes AXIN2 and TCF7L2 in gastric carcinomas with high microsatellite instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

regulation of Wnt signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

chondrocyte differentiation involved in endochondral bone morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

regulation of chondrocyte development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

secondary heart field specification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

negative regulation of canonical Wnt signaling pathway

Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

8 April 2019

Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

positive regulation of GTPase activity

IDA

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y2T1&geneProductId=UniProtKB:Q9Y2T1

beta-catenin-TCF complex assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

1 reference

8 April 2019

TAS

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

1 reference

8 April 2019

intramembranous ossification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1

negative regulation of osteoblast differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y2T1