(Q21111916)

http://www.ebi.ac.uk/interpro/protein/P32246

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

C-C chemokine binding

4 references

16 July 2018

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

16 July 2018

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

16 July 2018

A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

16 July 2018

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

chemokine (C-C motif) ligand 5 binding

IPI

4 references

16 July 2018

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

16 July 2018

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

16 July 2018

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

16 July 2018

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

signal transducer activity

IPI

1 reference

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

chemokine (C-C motif) ligand 7 binding

IEA

2 references

16 July 2018

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

16 July 2018

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

7 references

8 April 2019

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

chemokine receptor activity

IPI

3 references

8 April 2019

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

phosphatidylinositol phospholipase C activity

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

C-C chemokine receptor activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

C-C chemokine binding

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

chemokine (C-C motif) ligand 7 binding

3 references

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

chemokine (C-C motif) ligand 5 binding

5 references

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1(alpha), MIP-1(beta), and RANTES

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

7 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Human LZIP binds to CCR1 and differentially affects the chemotactic activities of CCR1-dependent chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Human LZIP induces monocyte CC chemokine receptor 2 expression leading to enhancement of monocyte chemoattractant protein 1/CCL2-induced cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

integral component of plasma membrane

1 reference

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

external side of plasma membrane

1 reference

16 July 2018

Cutaneous injection of human subjects with macrophage inflammatory protein-1 alpha induces significant recruitment of neutrophils and monocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

external side of plasma membrane

negative regulation of bone mineralization

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

positive regulation of cell migration

1 reference

8 April 2019

The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

positive regulation of cytosolic calcium ion concentration

1 reference

16 July 2018

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32246&geneProductId=UniProtKB:P32246

chemokine-mediated signaling pathway

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger

1 reference

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

cellular calcium ion homeostasis

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

positive regulation of osteoclast differentiation

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

dendritic cell chemotaxis

1 reference

8 April 2019

The multiple personalities of the chemokine receptor CCR7 in dendritic cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

negative regulation of gene expression

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

cell surface receptor signaling pathway

1 reference

8 April 2019

Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

calcium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

positive regulation of calcium ion transport

1 reference

8 April 2019

A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

3 references

8 April 2019

PLP2/A4 interacts with CCR1 and stimulates migration of CCR1-expressing HOS cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor

inflammatory response

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

calcium-mediated signaling

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32246

GPCR, rhodopsin-like, 7TM

has part(s)

1 reference

stated in

InterPro Release 71.0