(Q21112583)

English

Transferrin receptor

mammalian protein found in Homo sapiens

T9
p90
TFRC
transferrin receptor protein 1

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

Transferrin receptor-like, dimerisation domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02786

Transferrin receptor protein 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P02786

Putative uncharacterized transport proteins

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Transferrin receptor-like, dimerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Transferrin receptor protein 1/2, PA domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PA domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase M28 family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein homodimerization activity

determination method

1 reference

8 April 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

virus receptor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

transferrin receptor activity

determination method

4 references

17 October 2017

Transferrin receptor is necessary for development of erythrocytes and the nervous system

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

17 October 2017

Characterization of transferrin receptor released by K562 erythroleukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

17 October 2017

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

identical protein binding

determination method

3 references

8 April 2019

The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

double-stranded RNA binding

determination method

1 reference

8 April 2019

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

determination method

1 reference

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

protein binding

determination method

19 references

8 April 2019

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Mechanism for multiple ligand recognition by the human transferrin receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

TTP specifically regulates the internalization of the transferrin receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Cryo-EM structure of an essential Plasmodium vivax invasion complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

determination method

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

transferrin receptor activity

determination method

5 references

8 April 2019

Transferrin receptor is necessary for development of erythrocytes and the nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Characterization of transferrin receptor released by K562 erythroleukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

extracellular vesicle

determination method

1 reference

17 October 2017

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

integral component of membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

recycling endosome

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Rab11 endosomes contribute to mitotic spindle organization and orientation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

HFE-transferrin receptor complex

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

determination method

3 references

8 April 2019

Differential effects of antimycin A on endocytosis and exocytosis of transferrin also are observed for internalization and externalization of beta-adrenergic receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

blood microparticle

determination method

1 reference

17 October 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

determination method

3 references

8 April 2019

Characterization of transferrin receptor released by K562 erythroleukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

basolateral plasma membrane

determination method

1 reference

8 April 2019

Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

perinuclear region of cytoplasm

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Sec14 homology domain targets p50RhoGAP to endosomes and provides a link between Rab and Rho GTPases

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Ebola virus uses clathrin-mediated endocytosis as an entry pathway

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

extracellular space

determination method

1 reference

17 October 2017

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P02786&geneProductId=UniProtKB:P02786

determination method

clathrin-coated vesicle membrane

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

cytoplasmic vesicle

determination method

1 reference

8 April 2019

Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

extracellular space

determination method

1 reference

8 April 2019

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

blood microparticle

determination method

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

extracellular vesicle

determination method

1 reference

8 April 2019

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

biological process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

osteoclast differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

positive regulation of bone resorption

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

receptor-mediated endocytosis

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

regulation of cell population proliferation

determination method

1 reference

8 April 2019

A novel iron uptake mechanism mediated by GPI-anchored human p97

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

regulation of cell growth

determination method

1 reference

8 April 2019

A novel iron uptake mechanism mediated by GPI-anchored human p97

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

viral entry into host cell

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

cellular iron ion homeostasis

determination method

4 references

8 April 2019

Transferrin receptor is necessary for development of erythrocytes and the nervous system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Characterization of transferrin receptor released by K562 erythroleukemia cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

positive regulation of isotype switching

determination method

1 reference

8 April 2019

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

receptor internalization

determination method

1 reference

8 April 2019

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

transferrin transport

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

8 April 2019

HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

positive regulation of B cell proliferation

determination method

1 reference

8 April 2019

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

positive regulation of T cell proliferation

determination method

1 reference

8 April 2019

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

membrane organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

cellular response to leukemia inhibitory factor

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

iron ion transport

determination method

1 reference

8 April 2019

A novel iron uptake mechanism mediated by GPI-anchored human p97

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P02786

determination method

physically interacts with

Family with sequence similarity 209 member A

determination method

two-hybrid screening

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353224

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353224

ENSP00000376197

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376197

ENSP00000390133

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390133

ENSP00000402839

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000402839

ENSP00000414015

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000414015

Google Knowledge Graph ID

0 references

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(1 entry)

dewiki Transferrin-Rezeptor 1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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