Wikidata

(Q21112658)

English

autocrine motility factor receptor

mammalian protein found in Homo sapiens

  • RING finger protein 45
  • AMFR
  • gp78
  • AMF receptor
  • E3 ubiquitin-protein ligase AMFR
  • RING-type E3 ubiquitin transferase AMFR
In more languages

Statements

molecular function
ubiquitin-protein transferase activity
determination method
IDA
IMP
5 references
retrieved
9 May 2019
stated in
Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IMP
retrieved
9 May 2019
stated in
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IMP
retrieved
9 May 2019
stated in
Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IDA
retrieved
9 May 2019
stated in
CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IDA
retrieved
9 May 2019
stated in
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IDA
protein binding
determination method
IPI
12 references
retrieved
9 May 2019
stated in
Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Characterization of an Additional Binding Surface on the p97 N-Terminal Domain Involved in Bipartite Cofactor Interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Allosteric regulation of E2:E3 interactions promote a processive ubiquitination machine
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
retrieved
9 May 2019
stated in
Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IPI
cell component
biological process
ubiquitin-dependent ERAD pathway
determination method
IC
IDA
IMP
TAS
5 references
retrieved
9 May 2019
stated in
Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
TAS
retrieved
9 May 2019
stated in
Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IMP
retrieved
9 May 2019
stated in
The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IDA
retrieved
9 May 2019
stated in
Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation
GOA
curator
UniProt
UniProt protein ID
Q9UKV5
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IDA
retrieved
9 May 2019
stated in
Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UKV5
determination method
IC

Identifiers

MeSH descriptor ID
D060285
subject named as
Receptors, Autocrine Motility Factor
0 references
 
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