(Q21112885)

http://www.ebi.ac.uk/interpro/protein/Q9UFF9

Ribonuclease H superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UFF9

CCR4-NOT transcription complex subunit 8

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UFF9

1 reference

13 November 2019

1 reference

13 November 2019

3'-5'-exoribonuclease activity

1 reference

8 April 2019

Conservation of the deadenylase activity of proteins of the Caf1 family in human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

DNA-binding transcription factor activity

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

11 references

8 April 2019

MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

A directed protein interaction network for investigating intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

poly(A)-specific ribonuclease activity

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Conservation of the deadenylase activity of proteins of the Caf1 family in human

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

DNA-binding transcription factor activity

IBA

1 reference

8 April 2019

The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

1 reference

10 September 2018

Human Ccr4-Not complexes contain variable deadenylase subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UFF9&geneProductId=UniProtKB:Q9UFF9

intracellular anatomical structure

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

3 references

1 January 2018

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UFF9&geneProductId=UniProtKB:Q9UFF9

1 January 2018

The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UFF9&geneProductId=UniProtKB:Q9UFF9

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UFF9&geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

IBA

CCR4-NOT core complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

3 references

8 April 2019

The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

8 April 2019

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

nucleic acid phosphodiester bond hydrolysis

IDA

biological process

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

positive regulation of mRNA catabolic process

1 reference

8 April 2019

The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

transcription, DNA-templated

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

gene silencing by miRNA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

positive regulation of cell population proliferation

1 reference

8 April 2019

The Ccr4-NOT deadenylase subunits CNOT7 and CNOT8 have overlapping roles and modulate cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

exonucleolytic catabolism of deadenylated mRNA

IMP

1 reference

27 March 2018

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UFF9&geneProductId=UniProtKB:Q9UFF9

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

negative regulation of cell population proliferation

1 reference

1 January 2018

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UFF9&geneProductId=UniProtKB:Q9UFF9

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

RNA phosphodiester bond hydrolysis, exonucleolytic

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

nuclear-transcribed mRNA poly(A) tail shortening

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

regulation of transcription, DNA-templated

1 reference

8 April 2019

The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9

negative regulation of translation

NAS

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UFF9